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Pharmacology, Exploratory, Toxicology

Support your preclinical studies with advanced cell models for toxicity testing from ATCC. Explore our resource below to get started.

Preclinical Toxicology PK Metabolism

Need a functional model to explore the ADME of a new chemical entity? Discover how neurological and renal cell models can support your metabolic stability, metabolite identification, and drug-drug interaction assays.

Modeling, Screening, Characterizing

Are you in the preliminary stages of toxicity testing? Start on the path to success with our complete solution of cell lines, media, and reagents.

Cell Lines for Toxicology

Authenticated ATCC cells ensure your toxicology results are accurate. Explore our complete set of solutions today!

Cell models that reflect true physiology

The FDA requires confirmation of preliminary screening and characterization studies for new drug applications with experiments performed in more physiologically relevant models. To help the success of your preclinical studies, ATCC provides advanced cell models for toxicity testing, such as differentiated iPSCs and primary and hTERT-immortalized primary cells.

  • Differentiated iPSCs – These cells fulfill the need for a consistent source of cells with physiological relevance; they provide large numbers of cells that can be differentiated into a variety of functional cell types, affording the necessary biological relevance with minimal lot-to-lot variability.
  • Primary Cells – These cells are the most physiologically relevant model available. To ensure the success of your primary cultures, we offer a complete solution of cells, media, and supplements.
  • hTERT-immortalized Primary Cells – These modified primary cells provide physiological relevance, but without the limitation of proliferation. ATCC offers hTERT-immortalized cells derived from kidney, skin, airway, and vasculature.

Read our application notes

hTERT-immortalized and Primary Keratinocytes

Explore our data confirming that an immortalized keratinocyte cell line is able to differentiate into organotypic skin equivalents in a 3D culture model.

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Human Bronchial/Tracheal Epithelial Cells

This study examines the ability of primary human bronchial/tracheal epithelial cells to differentiate into mature airway tissue using an air-liquid culture interface model.

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Watch our webinar to learn how hTERT-immortalized cells can improve your toxicity assays