Cell models that reflect true physiology
The FDA requires confirmation of preliminary screening and characterization studies for new drug applications with experiments performed in more physiologically relevant models. To help the success of your preclinical studies, ATCC provides advanced cell models for toxicity testing, such as differentiated iPSCs and primary and hTERT-immortalized primary cells.
- Differentiated iPSCs – These cells fulfill the need for a consistent source of cells with physiological relevance; they provide large numbers of cells that can be differentiated into a variety of functional cell types, affording the necessary biological relevance with minimal lot-to-lot variability.
- Primary Cells – These cells are the most physiologically relevant model available. To ensure the success of your primary cultures, we offer a complete solution of cells, media, and supplements.
- hTERT-immortalized Primary Cells – These modified primary cells provide physiological relevance, but without the limitation of proliferation. ATCC offers hTERT-immortalized cells derived from kidney, skin, airway, and vasculature.
Read our application notes
hTERT-immortalized and Primary Keratinocytes
Explore our data confirming that an immortalized keratinocyte cell line is able to differentiate into organotypic skin equivalents in a 3D culture model.
Human Bronchial/Tracheal Epithelial Cells
This study examines the ability of primary human bronchial/tracheal epithelial cells to differentiate into mature airway tissue using an air-liquid culture interface model.
