Cell models that reflect true physiology
The FDA requires confirmation of preliminary screening and characterization studies for new drug applications with experiments performed in more physiologically relevant models. To help the success of your preclinical studies, ATCC provides advanced cell models for toxicity testing, such as differentiated iPSCs and primary and hTERT-immortalized primary cells.
- Differentiated iPSCs – These cells fulfill the need for a consistent source of cells with physiological relevance; they provide large numbers of cells that can be differentiated into a variety of functional cell types, affording the necessary biological relevance with minimal lot-to-lot variability.
- Primary Cells – These cells are the most physiologically relevant model available. To ensure the success of your primary cultures, we offer a complete solution of cells, media, and supplements.
- hTERT-immortalized Primary Cells – These modified primary cells provide physiological relevance, but without the limitation of proliferation. ATCC offers hTERT-immortalized cells derived from kidney, skin, airway, and vasculature.
Read our application notes
hTERT-immortalized and Primary Keratinocytes
Explore our data confirming that an immortalized keratinocyte cell line is able to differentiate into organotypic skin equivalents in a 3D culture model.
Human Bronchial/Tracheal Epithelial Cells
This study examines the ability of primary human bronchial/tracheal epithelial cells to differentiate into mature airway tissue using an air-liquid culture interface model.
Explore our products for pharmacology, exploratory, and toxicology research
hTERT-immortalized Primary Cells
There is a lack of in vitro models that durably and correctly recapitulate in vivo physiology. hTERT-immortalized primary cells solve the problem of limited biological relevancy in cell-based assays: this versatile cell type displays the growth characteristics of continuous cell lines without the loss of normal physiologies. They conveniently allow for large-scale screening of toxicology compounds while avoiding lot to lot variability.
Order hTERT-derived primary cellsPrimary Human Hepatocytes
Primary human hepatocytes retain many of the key functions of the liver in vitro, providing an indispensable tool for predictive drug development and toxicity testing. ATCC supports these essential studies with HepatoXcell™—a comprehensive product suite of high-quality primary human hepatocytes and media. Our primary human hepatocytes are sourced from multiple donors, exhibit excellent viability, and retain key liver functions, making them ideal for drug metabolism, toxicity studies, and liver disease research.
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Differentiated iPSCs
Toxicologists struggle to find cell models with high physiological relevance and the ability to be run in an assay over and over again without introducing variability. To fulfill this need, ATCC scientists have differentiated induced pluripotent stem cells (iPSCs) into widely used cells such as mesenchymal stem cells, CD34+ cells, and monocytes. These differentiated cells can be used to build physiologically relevant cell-based assays for drug development in fields such as regenerative medicine, hematology, oncology, and toxicology.
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Human Primary Cells
Isolated directly from tissue and untransformed, primary cells are the most physiologically relevant models available. ATCC offers a wide variety of human primary cells from normal or diseased donors that can be used as physiologically relevant models for drug screening and toxicity studies. In addition, we provide a complete solution for primary cell growth, including tissue-specific media, supplements, and other reagents specially formulated to ensure the robust growth of your primary cells.
Order primary cells
hTERT-immortalized Primary Cells
There is a lack of in vitro models that durably and correctly recapitulate in vivo physiology. hTERT-immortalized primary cells solve the problem of limited biological relevancy in cell-based assays: this versatile cell type displays the growth characteristics of continuous cell lines without the loss of normal physiologies. They conveniently allow for large-scale screening of toxicology compounds while avoiding lot to lot variability.
Order hTERT-derived primary cellsPrimary Human Hepatocytes
Primary human hepatocytes retain many of the key functions of the liver in vitro, providing an indispensable tool for predictive drug development and toxicity testing. ATCC supports these essential studies with HepatoXcell™—a comprehensive product suite of high-quality primary human hepatocytes and media. Our primary human hepatocytes are sourced from multiple donors, exhibit excellent viability, and retain key liver functions, making them ideal for drug metabolism, toxicity studies, and liver disease research.
Explore hepatocytes
Differentiated iPSCs
Toxicologists struggle to find cell models with high physiological relevance and the ability to be run in an assay over and over again without introducing variability. To fulfill this need, ATCC scientists have differentiated induced pluripotent stem cells (iPSCs) into widely used cells such as mesenchymal stem cells, CD34+ cells, and monocytes. These differentiated cells can be used to build physiologically relevant cell-based assays for drug development in fields such as regenerative medicine, hematology, oncology, and toxicology.
Order iPSC-derived primary cells
Human Primary Cells
Isolated directly from tissue and untransformed, primary cells are the most physiologically relevant models available. ATCC offers a wide variety of human primary cells from normal or diseased donors that can be used as physiologically relevant models for drug screening and toxicity studies. In addition, we provide a complete solution for primary cell growth, including tissue-specific media, supplements, and other reagents specially formulated to ensure the robust growth of your primary cells.
Order primary cellsWatch our webinar to learn how hTERT-immortalized cells can improve your toxicity assays
Featured products
Mammary Epithelial Cells-Normal
Optimal serum-free culture model for many research areas including breast cancer development, three-dimensional culture, and carcinogen screening.
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Prostate Epithelial Cells-Normal
Model for studying hormonal regulation of the prostate, regulation and control of the secretory function of prostate cells, and prostate cancer.
Order NowhTERT EP156T Prostate Cells
Normal hTERT-immortalized prostate cells are valuable in prostate cancer progression.
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iPSC-derived Monocytes
These cells can be differentiated into functionally active macrophages and dendritic cells or used out of the vial in MAT assay, drug development, toxicity screening, and cancer immunology experiments.
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iPSC-derived Mesenchymal Stem Cells
Ideal for applications such as bone cell lineage differentiation, regenerative medicine, cell therapy, exosome research, and cancer immunology.
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iPSC-derived CD34+ Cells
This cell line is easily incorporated into drug development, toxicity screening, and cancer immunology experiments due to its reduced lot-to-lot variability.
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RPTEC/TERT1 OCT2
Cell line stably expressing SLC transporter hOCT2 for use in transport studies and kidney drug toxicity screening and research.
Order NowModels with Stable OCT2
RPTEC/TERT1 cell line stably expressing SLC transporter hOCT2 is valuable in transport studies.
Learn MorePrimary Coronary Artery Endothelial
Normal cells for angiogenesis, arteriolosclerosis, hypertension, oncology, drug screening, inflammation, and vasodilator function.
Start NowPrimary Dermal Microvascular Endothelial Cells
Adherent neonatal cells for drug screening, angiogenesis, oncology, inflammation, and intercellular communication.
Order TodayPrimary Umbilical Vein Endothelial Cells
Essential for immune response, cellular response to viral or bacterial infection, oxidative stress, tubule formation, and more.
Get the CellsHuman Primary Cervical Epithelial Cells
Cervical epithelial cells provide an ideal in vitro model for studying the pathophysiology of cervical polyps, HPV, and cervical cancer.
Explore NowMammary Epithelial Cells-Normal
Optimal serum-free culture model for many research areas including breast cancer development, three-dimensional culture, and carcinogen screening.
Get the Standard
Prostate Epithelial Cells-Normal
Model for studying hormonal regulation of the prostate, regulation and control of the secretory function of prostate cells, and prostate cancer.
Order NowhTERT EP156T Prostate Cells
Normal hTERT-immortalized prostate cells are valuable in prostate cancer progression.
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iPSC-derived Monocytes
These cells can be differentiated into functionally active macrophages and dendritic cells or used out of the vial in MAT assay, drug development, toxicity screening, and cancer immunology experiments.
Order Monocytes
iPSC-derived Mesenchymal Stem Cells
Ideal for applications such as bone cell lineage differentiation, regenerative medicine, cell therapy, exosome research, and cancer immunology.
Get the cells
iPSC-derived CD34+ Cells
This cell line is easily incorporated into drug development, toxicity screening, and cancer immunology experiments due to its reduced lot-to-lot variability.
Order now
