iPSC-derived Mesenchymal Stem Cells; BYS0112
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A distinct advantage of incorporating iPSC-derived MSCs: While there will be lot-to-lot donor variability in primary MSC, there will be no donor variability in iPSC-derived MSC from multiple lots as they are all derived from the parental iPSC line (ATCC ACS-1026). In addition, there is an availability of large number vials of cells from a single donor.
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Zhong H, et al. Human pluripotent stem cell-derived mesenchymal stem cells prevent chronic allergic airway inflammation via TGF-β1-Smad2/Smad3 signaling pathway in mice. Mol Immunol 109: 51-57, 2019. PubMed: 30852246
Jeon OH, et al. Human iPSC-derived osteoblasts and osteoclasts together promote bone regeneration in 3D biomaterials. Sci Rep 6: 26761, 2016. PubMed: 27225733