Preclinical Toxicology PK Metabolism

Functional models for exploring the ADME of a new chemical entity

Testing for absorption, distribution, metabolism, and excretion (ADME) is crucial to moving your product to market. Get closer results to those observed in vivo and rule out possible toxicities faster by using our entire ADME portfolio, featuring our primary human hepatocytes, neural progenitor cells, and hTERT-immortalized renal transport protein-expressing kidney cells. ATCC is here to support your metabolic stability, metabolite identification, and drug-drug interaction assays with our neurological and renal cell models.

Scientist using pipette to fill well-plate

Primary Human Hepatocytes

Primary human hepatocytes retain many of the key functions of the liver in vitro, providing an indispensable tool for predictive drug development and toxicity testing. ATCC supports these essential studies with HepatoXcell™—a comprehensive product suite of high-quality primary human hepatocytes and media. Our primary human hepatocytes are sourced from multiple donors, exhibit excellent viability, and retain key liver functions, making them ideal for drug metabolism, toxicity studies, and liver disease research.

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Neurons derived from human neural stem cells Credit Yirui Sun.

Neural Progenitor Cells

Optimized cell lines are essential for testing the neurotoxicity of new chemical entities. ATCC offers a complete system of normal and Parkinson's disease tri-lineage–capable, neural progenitor cells (NPCs), lineage marker–labeled NPCs, and expansion and differentiation media. Work with differentiating or terminally differentiated neurons, astrocytes, and oligodendrocytes much sooner—yield experimental results faster.

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Blue and pink hTERT renal proximal tubular epithelial cells.

Renal SLC Transporter Cells

Toxicologists struggle to find kidney models with high physiological relevance and inter-experimental reproducibility. To fulfill this need, ATCC scientists have created biologically functional renal epithelial tubule cells using a well-characterized hTERT-immortalized RPTEC that stably overexpress the OAT1, OCT2, or OAT3 gene; these modified cells provide kidney tissue-relevant results, improved consistency over time, and predictability for clinical trials.

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