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Preclinical Toxicology PK Metabolism

Explore our resources below to discover how neurological and renal cell models can support your metabolic stability, metabolite identification, and drug-drug interaction assays.

Pharmacology, Exploratory, Toxicology

Do you need a model that reflects true physiology? Get started with differentiated iPSCs and primary and hTERT-immortalized primary cells.

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Modeling, Screening, Characterizing

Are you in the preliminary stages of toxicity testing? Start on the path to success with our complete solution of cell lines, media, and reagents.

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Cell Lines for Toxicology

Authenticated ATCC cells ensure your toxicology results are accurate. Explore our complete set of solutions today!

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Functional models for exploring the ADME of a new chemical entity

Testing for absorption, distribution, metabolism, and excretion (ADME) is crucial to moving your product to market. Get closer results to those observed in vivo and rule out possible toxicities faster by using our entire ADME portfolio, featuring our primary human hepatocytes, neural progenitor cells, and hTERT-immortalized renal transport protein-expressing kidney cells. ATCC is here to support your metabolic stability, metabolite identification, and drug-drug interaction assays with our neurological and renal cell models.

Scientist using pipette to fill well-plate

Primary Human Hepatocytes

Primary human hepatocytes retain many of the key functions of the liver in vitro, providing an indispensable tool for predictive drug development and toxicity testing. ATCC supports these essential studies with HepatoXcell™—a comprehensive product suite of high-quality primary human hepatocytes and media. Our primary human hepatocytes are sourced from multiple donors, exhibit excellent viability, and retain key liver functions, making them ideal for drug metabolism, toxicity studies, and liver disease research.

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Neurons derived from human neural stem cells Credit Yirui Sun.

Neural Progenitor Cells

Optimized cell lines are essential for testing the neurotoxicity of new chemical entities. ATCC offers a complete system of normal and Parkinson's disease tri-lineage–capable, neural progenitor cells (NPCs), lineage marker–labeled NPCs, and expansion and differentiation media. Work with differentiating or terminally differentiated neurons, astrocytes, and oligodendrocytes much sooner—yield experimental results faster.

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Blue and pink hTERT renal proximal tubular epithelial cells.

Renal SLC Transporter Cells

Toxicologists struggle to find kidney models with high physiological relevance and inter-experimental reproducibility. To fulfill this need, ATCC scientists have created biologically functional renal epithelial tubule cells using a well-characterized hTERT-immortalized RPTEC that stably overexpress the OAT1, OCT2, or OAT3 gene; these modified cells provide kidney tissue-relevant results, improved consistency over time, and predictability for clinical trials.

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Read our application notes

3D Rendering of gray neurons

Human iPSC-derived Neural Progenitor Cells

Explore the differentiation of neural progenitor cells into multiple neuron types and the use of these cells in toxicological studies.

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Kidney glomeruli

Renal Solute Carrier Uptake Models

Learn more about the creation and application of hTERT-immortalized human primary RPTECs that stably express the OAT1, OCT2, or OAT3 proteins.

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Watch our webinar to learn about the use of neural progenitor cells in toxicology studies

Featured products

Green and red dopaminergic Diff Tuj1 DAPI cells.

Neural Progenitor Cell Dopaminergic Differentiation Kit

Media specially designed for the dopaminergic differentiation of iPSC-derived neural progenitor cells (NPCs).

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Green and blue dopaminergic neural progenitor cells

Growth Kit for Neural Progenitor Cell Expansion

Media specially designed for the expansion of iPSC-derived neural progenitor cells (NPCs).

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Green Oligodentrocytes neural progenitor cells.

Neural Progenitor Cells from Normal Tissue

Human iPSC-derived NPCs for neuronal differentiation and drug toxicity screening.

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Red and purple renal proximal tubular epithelial cells.

RPTEC/TERT1 OAT1

RPTEC/TERT1-OAT1 expresses SLC transporter hOAT1(SLC22A6) and has applications in kidney research and transport studies.

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Blurry, fluorescent purple renal proximal tubular epithelial cells.

RPTEC/TERT1 OAT3

This hTERT-immortalized SLC transporter cell model stably expresses hOAT3(SLC22A8). It has applications in kidney drug toxicity screening.

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Connecting, fluorescent green strands and blue spheres of renal proximal tubular epithelial cells.

RPTEC/TERT1 OCT2

The RPTEC/TERT1 cell line stably expresses SLC transporter hOCT2(SLC22A2). This cell model can be used for kidney drug toxicity screening.

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Explore our entire toxicology portfolio