Preclinical Toxicology PK Metabolism

Explore our resources below to discover how neurological and renal cell models can support your metabolic stability, metabolite identification, and drug-drug interaction assays.

Pharmacology, Exploratory, Toxicology

Do you need a model that reflects true physiology? Get started with differentiated iPSCs and primary and hTERT-immortalized primary cells.

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Modeling, Screening, Characterizing

Are you in the preliminary stages of toxicity testing? Start on the path to success with our complete solution of cell lines, media, and reagents.

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Cell Lines for Toxicology

Authenticated ATCC cells ensure your toxicology results are accurate. Explore our complete set of solutions today!

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Functional models for exploring the ADME of a new chemical entity

Testing for absorption, distribution, metabolism, and excretion (ADME) is crucial to moving your product to market. Get closer results to those observed in vivo and rule out possible toxicities faster by using our entire ADME portfolio, featuring our hTERT-immortalized renal transport protein-expressing kidney cells. ATCC is here to support your metabolic stability, metabolite identification, and drug-drug interaction assays with our neurological and renal cell models.

Neural Progenitor Cells – Ideal in vitro cell models, these can be induced to differentiate into 3 different early neuron stages
Renal Kidney SLC Transporter Cells – Can be used to monitor the renal solute transport of compounds or assess the renal toxicity of novel agents.

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Human iPSC-derived Neural Progenitor Cells

Explore the differentiation of neural progenitor cells into multiple neuron types and the use of these cells in toxicological studies.

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Explore our products for preclinical toxicology

Neurons derived from human neural stem cells.

Neural Progenitor Cells

Optimized cell lines are essential for testing the neurotoxicity of new chemical entities. ATCC offers a complete system of normal and Parkinson's disease tri-lineage–capable, neural progenitor cells (NPCs), lineage marker–labeled NPCs, and expansion and differentiation media. Work with differentiating or terminally differentiated neurons, astrocytes, and oligodendrocytes much sooner—yield experimental results faster.

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Blue and pink hTER renal proximal tubular epithelial cells.

Renal SLC Transporter Cells

Toxicologists struggle to find kidney models with high physiological relevance and inter-experimental reproducibility. To fulfill this need, ATCC scientists have created biologically functional renal epithelial tubule cells using a well-characterized hTERT-immortalized RPTEC that stably overexpress the OAT1, OCT2, or OAT3 gene; these modified cells provide kidney tissue-relevant results, improved consistency over time, and predictability for clinical trials.

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