Solute transporter carrier (SLC) cells play an important role in the absorption, distribution, and clearance of a wide variety of drugs from the kidney and other organs.
Researchers need models of in vitro kidney transporters that have normal human kidney origin, functioning transporters, clinical predictability, and consistent data output for drug interaction studies. Unfortunately, primary renal epithelial cells lose OAT1, OCT2, and OAT3 transporter expression quickly in culture.
ATCC has been able to utilize hTERT-immortalized primary renal proximal tubule epithelial cells to create kidney transporter cells that stably overexpress either the OAT1, OCT2, or OAT3 gene for drug toxicity screening and more.
Renal Solute Carrier Models Maintain Transporter Expression
Modified renal epithelial cell lines maintain kidney transporter expression over time and provide physiologically relevant data regarding human kidney transporter functions. These models are valuable tools for high throughput kidney drug toxicity screening to test the effects of exogenous compounds on renal membrane transporter function.See the Data