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White Papers

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ATCC is dedicated to accelerating biological research and advancing global health by facilitating communication and ideas among scientists. White papers offer a powerful communication tool that helps inform researchers on important issues and possible solutions. Browse our growing collection of white papers to explore a variety of topics ranging from antimicrobial resistance and cancer research to the importance of authentication and the need for standards.
Close-up of API strip that contains media of various colors. White paper

Authentication of Prokaryotes at ATCC

Authenticated reference materials are essential for assay reproducibility and data integrity. Explore how prokaryotes are authenticated at ATCC.

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Six luminescent blue spider-like legs of a bacteriophage on a beige surface. White paper

Bacteriophage Therapy - An Alternative Approach for Treating Multidrug-resistant Infections

Multidrug resistance poses a significant public health threat. Alternative treatment such as bacteriophage therapy may offer a promising mechanism for the eradication of infection.

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Closeup of a black and red firefly showing his light while standing on a green leaf. White paper

Bioluminescence Imaging of Live Animal Models: Shedding New Light on an Old Problem

In this article, we review the current models and techniques used in cancer research and discuss the use of bioluminescence imaging for the precise histological measurement of tumors.

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Fingers holding a test tube containing a silver, red, and blue DNA double helix. White paper

Challenges and Solutions in the Development and Validation of Molecular-based Assays

Discover more about the challenges associated with evaluating the analytical performance of a molecular-based assay and find guidance on selecting the ideal reference materials.

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Sarcoma soft tissue cancer cells. White paper

CRISPR/Cas9-engineered Cancer Models: The Next Step Forward for Targeted Cancer Therapy

ATCC has been steadily expanding an array of CRISPR/Cas9 genome-editing capabilities and leveraging its extensive library of human cell lines for the development of custom-engineered, biomarker-specific human cancer models.

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Human breast cancer cell dividing. White paper

Drug Resistance in Cancer: Mechanisms and Models

The next generation of advanced cancer models are vital tools for furthering our understanding drug-resistance mechanisms and will help lead to faster development cycles and lower failure rates for both anticancer drug development and evaluation of combination therapy strategies.

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Close-up of rows of pipettes, filled with clear green media, with tips in cell culture well plate. White paper

Enhance the Development of Rapid Microbiological Methods

Molecular-based rapid microbiological methods (RMM) are contemporary technologies used to quickly and sensitively detect, enumerate, and identify microorganisms.

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Blue and black cells. White paper

Improving Accuracy and Reproducibility in Life Science Research

Too often, scientific findings in biomedical research cannot be reproduced. Here, we review several predominant factors affecting reproducibility and outline efforts aimed at improving the situation.

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Dark green, floating rods of bacteria. White paper

Infectious Disease Assay Development: Choosing the Appropriate External Controls

Here, we will discuss the importance of choosing the appropriate external controls, and will provide information on how to select the appropriate cultures and nucleic acids for your tests.

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Blue DNA strand with sides made of light blue balls. White paper

Infectious Disease Assay Development: Determining the Limit of Detection

Determining the detection limit is an essential part of infectious disease assay development and design. Here, we will discuss the importance of determining the detection limit in establishing analytical sensitivity, and will provide information on how to establish this parameter when evaluating your experimental design.

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Green, rod-shaped Escherichia coli bacteria. White paper

Infectious Disease Assay Development: Establishing Inclusivity/Exclusivity

Ensuring analytical specificity is critical in assay development and validation. Through the use of a diverse array of authenticated, highly characterized strains that represent your target organism or non-target species, assay specificity can be established.

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Yolk-like spheres of Enterobacter sakazakii bacteria. White paper

Microbiological Quality Control of Pharmaceutical Products

To ensure product safety, pharmaceutical companies must be versed in the important role of microbiological testing in product research and development, process validation, manufacturing, and quality control. ATCC supports the maintenance of product integrity, reputation, and safety by providing top-quality, fully characterized strains in a ready-to-use, familiar format.

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Blue m-hyorhinis mycoplasma cells. White paper

Mycoplasma Quality Control of Cell Substrates and Biopharmaceuticals

In this article, we will discuss the effects of mycoplasma contamination, how this form of adulteration can affect cell-based drug development, and several quality control techniques and related products that can be used in the detection of mycoplasma contamination.

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Several floating strings of purple drug-resistant Streptococcus pneumoniae spheres. White paper

Pneumococcal Polysaccharides - Advancing Research and Development

In this article, we discuss the importance of capsular polysaccharides in S. pneumoniae infection and describe the use of purified serotype-specific polysaccharides in the development and evaluation of pneumococcal vaccines, the verification of novel immunoassays, and tracking bacterial disease epidemiology

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Blue well plate. White paper

Reporter-Labeled Strains: Powerful Tools for Microbiology Research

Reporter systems provide unique and powerful tools for microbiological research. By developing reporter-labeled strains using authenticated microorganisms, or by acquiring these strains from a reliable source, the scientific community can come one step closer to understanding a number of complex microbial systems and processes.

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Large cryopreservation storage tanks at biorepository. White paper

Storing Biological Materials for Pharmaceutical R&D

High-quality biological samples have become essential tools for supporting research and development (R&D) in the pharmaceutical industry. Biorepository facilities, which are dedicated to the collection, handling, storage, and distribution of biological materials for use in research, are the places of choice for maintaining these biomaterials. Read this white paper for an overview of the relationship between the evolving practices of modern biorepositories and the current trends in pharmaceutical R&D.

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Purple and red TEM Zika virus cells. White paper

Synthetic RNA for the Development and Evaluation of In Vitro Diagnostic Devices Designed to Detect Dengue, Chikungunya, and Zika

The accurate and rapid diagnosis of vector-borne diseases through validated diagnostic methods is critical in enabling prompt treatment and controlling microbial dissemination. Discover how synthetic molecular standards can help.

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Microbes and bacteria in bright colors combined to form the shape of a human head. Illustration. White paper

The Need for Standards in Human Microbiome Research

The human microbiome changes over time with respect to lifestyle, the environment, and exposure to disease. This individual biology is a powerful tool for personalized healthcare and precision medicine.

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Row of clear sealed serum vials. White paper

The Need for Tuberculosis Reference Standards in Vaccine Development

Through the use of a single, consensus, biological standard that demonstrates high levels of protection when used in vaccine development, manufacturers can come one step closer to improving tuberculosis vaccine performance.

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Round, floating, purple-blue balls of staphylococcus aureus bacteria. White paper

The Rise of Multidrug-Resistant Strains and Need for New Therapeutic Approaches

Multidrug-resistant microbial strains are continually implicated in a number of infections worldwide, resulting in significant increases in morbidity, mortality, and healthcare expense. To help control the emergence and spread of these pathogens, discovering new and effective treatment methods is of the upmost importance.

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Application Notes

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Purple, red and black human umbilical vein endothelial cells.

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