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White Papers

Female and male scientist in lab coats looking at laptop in a lab.
ATCC is dedicated to accelerating biological research and advancing global health by facilitating communication and ideas among scientists. White papers offer a powerful communication tool that helps inform researchers on important issues and possible solutions. Browse our growing collection of white papers to explore a variety of topics ranging from antimicrobial resistance and cancer research to the importance of authentication and the need for standards.
Close-up of API strip that contains media of various colors. White paper

Authentication of Prokaryotes at ATCC

Read this white paper to explore how prokaryotes are authenticated at ATCC.

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Six luminescent blue spider-like legs of a bacteriophage on a beige surface. White paper

Bacteriophage Therapy An Alternative Approach for Treating Multidrug Resistant Infections

Read this white paper to learn more about multidrug resistance and how alternative treatment such as bacteriophage therapy may offer a promising mechanism for the eradication of infection.

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Closeup of a black and red firefly showing his light while standing on a green leaf. White paper

Bioluminescence Imaging of Live Animal Models

In this white paper we review the current models and techniques used in cancer research and discuss the use of bioluminescence imaging for the precise histological measurement of tumors.

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Fingers holding a test tube containing a silver, red, and blue DNA double helix. White paper

Challenges and solutions in the development and validation of molecular based assays

Discover more about the challenges associated with evaluating the analytical performance of a molecular assay and find guidance on selecting the ideal reference materials.

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Red, purple, green, and yellow A549 CRISPR cells. White paper

CRISPRCas9 engineered cancer models the next step forward

ATCC has been steadily expanding an array of CRISPR/Cas9 genome-editing capabilities and leveraging its extensive library of human cell lines for the development of custom-engineered, biomarker-specific human cancer models.

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Human breast cancer cell dividing. White paper

Drug Resistance in Cancer

This white paper examines how the next generation of advanced cancer models are vital tools for furthering our understanding drug-resistance mechanisms and will help lead to faster development cycles and lower failure rates for both anticancer drug development and evaluation of combination therapy strategies.

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Close-up of rows of pipettes, filled with clear green media, with tips in cell culture well plate. White paper

Enhance the Development of Rapid Microbiological Methods

Read this white paper to learn how molecular-based rapid microbiological methods provide contemporary technologies used to quickly and sensitively detect, enumerate, and identify microorganisms.

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Red tipped multi-channel pipettor above multicolored well plates. White paper

Improving accuracy and reproducibility in life science research

In this white paper, we review several predominant factors affecting reproducibility in life science research and outline efforts aimed at improving the situation.

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Dark green, floating rods of bacteria. White paper

Infectious Disease Assay Development: Choosing the Appropriate External Controls

Here, we will discuss the importance of choosing the appropriate external controls, and will provide information on how to select the appropriate cultures and nucleic acids for your tests.

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Blue DNA strand with sides made of light blue balls. White paper

Infectious disease assay development determining the limit of detection

In this white paper, we will discuss the importance of determining the detection limit in establishing analytical sensitivity, and will provide information on how to establish this parameter when evaluating your experimental design.

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Yellow balls of Staphylococcus, aureus bacteria. White paper

Infectious disease assay development establishing inclusivity exclusivity

In this white paper, we discuss the importance of inclusivity/exclusivity testing, and will provide information on how to establish these parameters when evaluating your experimental design.

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Yolk-like spheres of Enterobacter sakazakii bacteria. White paper

Microbiological Quality Control of Pharmaceutical Products

To ensure product safety, pharmaceutical companies must be versed in the important role of microbiological testing in product research and development, process validation, manufacturing, and quality control. Read this white paper to learn how ATCC supports the maintenance of product integrity, reputation, and safety by providing top-quality, fully characterized strains in a ready-to-use, familiar format.

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Blue m-hyorhinis mycoplasma cells. White paper

Mycoplasma quality control of cell substrates and biopharmaceuticals

In this article, we will discuss the effects of mycoplasma contamination, how this form of adulteration can affect cell-based drug development, and several quality control techniques and related products that can be used in the detection of mycoplasma contamination.

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Strands of pearl-like purple Streptococci bacteria. White paper

Pneumococcal Polysaccharides – Advancing Research and Development

In this white paper, we discuss the importance of capsular polysaccharides in Streptococcus pneumoniae infection and describe the use of purified serotype-specific polysaccharides in the development and evaluation of pneumococcal vaccines, the verification of novel immunoassays, and tracking bacterial disease epidemiology.

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Petri dish filled with bright-blue and green media and cells in a line and spot pattern. White paper

Reporter-Labeled Strains Powerful Tools for Microbiology Research

In this white paper, we highlight the reporters commonly used in microbiological research and provide detail on the various applications of reporter-labeled strains.

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Large cryopreservation storage tanks at biorepository. White paper

Storing Biological Materials for Pharmaceutical R&D

Read this white paper for an overview of the relationship between the evolving practices of modern biorepositories and the current trends in pharmaceutical R&D.

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Closeup of Culex tarsalis mosquito biting skin. White paper

Synthetic Nucleic Acids for the Development and Evaluation of In Vitro Diagnostic Devices

In this white paper, we discuss the co-circulation and potential co-infection of the mosquito-borne Dengue (DENV), Chikungunya (CHIKV), and Zika (ZIKV) viruses; the challenges associated with the identification and discernment of these viruses; and the need for authenticated control materials for the validation of in vitro diagnostic tools.

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Microbes and bacteria in bright colors combined to form the shape of a human head. Illustration. White paper

The Need for Standards in Human Microbiome Research

The human microbiome changes over time with respect to lifestyle, the environment, and exposure to disease. This individual biology is a powerful tool for personalized healthcare and precision medicine.

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Row of clear sealed serum vials. White paper

The Need for Tuberculosis Reference Standards in Vaccine Development

In this white paper, we discuss how vaccine manufacturers can improve tuberculosis vaccine performance by utilizing a single, consensus biological reference standard that demonstrates high levels of protection when used in vaccine development.

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Round, floating, purple-blue balls of staphylococcus aureus bacteria. White paper

The Rise of Multidrug-Resistant Strains and Need for New Therapeutic Approaches

In this white paper, we discuss the growing threat of antimicrobial resistance, novel therapeutic approaches, and the importance of antimicrobial-resistant reference strains in reducing the emergence and spread of multidrug-resistant infections.

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