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Toxicology

Blue and pink hTER renal proximal tubular epithelial cells.

Authenticated ATCC cells ensure your toxicology results are accurate

As scientists, we are challenged to identify the adverse effects of a broad range of substances to protect people and the environment. It is critical that the standards and model organisms used in toxicological testing are reliable and authenticated. 

ATCC provides the credible models that toxicologists need to perform standardized, reliable, and reproducible toxicology studies. ATCC cells, media, and reagents allow you to investigate renal, neural, airway, and skin toxicity for such applications as high-content screening, 3D culture, spheroid culture, permeability assays, metabolic stability and survival studies, transport activity measurement, and more. Our toxicological tools can be used to identify responses to environmental insults or to screen pharmaceutical compounds.

Cells for hepatic and renal clearance research

ATCC has models to get your results close to in vivo states and rule out possible toxicities faster:

  • ADME portfolio, featuring our hTERT-immortalized renal transport protein-expressing kidney cells
  • Renal and hepatic models support your metabolic stability, metabolite identification, and drug-drug interaction assays

Cells for neurotoxicity studies

ATCC cells from neural tissues and neural progenitor cells can be easily differentiated into those needed for neurotoxicity studies. You are able to work with differentiating or terminally differentiated neurons, astrocytes, and oligodendrocytes sooner to yield faster experimental results. 

ATCC provides: 

  • Brain-derived cell lines
  • Neural progenitor cells
  • hTERT-immortalized primary Schwaan cells

Cells for dermal toxicology

ATCC has cells that can be utilized to create 3D skin models or used in basic assays, including primary cells and hTERT-immortalized cells for modeling of the skin, and:

  • Human primary keratinocytes
  • Human primary melanocytes
  • hTERT-immortalized primary skin cells
  • Skin cell lines

Cells to study airway toxicity

ATCC offers primary airway epithelial cells, smooth muscle cells (SMCs), and fibroblasts, as well as growth media and media supplements for in vitro models, to boost the scientific relevance of your upper respiratory studies. Our materials make it simple to test for tissue variability, cytotoxicity, and more:

  • Human primary airway cells
  • hTERT-immortalized primary airway cells
  • Airway cell lines

Toxicology resources

hTERT kidney renal proximal tubular epithelial cells.

Uptake Model for Drug Toxicity Studies

ATCC created three different hTERT-immortalized human primary renal proximal tubule epithelial cells (RPTEC) that stably express the OAT1, OCT2, and OAT3 proteins.

Download the Application Note
Red IPSC colony nanog cells.

iPSC-derived Primary Cells in Toxicological Assays

iPSC-derived primary cells lend the ability to run large toxicity studies and drug screens with highly biologically relevant cells.

Download the Presentation

Toxicology protocols

Green and blue NuLi lung epithelial small airway cells.

hTERT-immortalized Cell Culture Guide

Follow these cell culture techniques to guarantee the viability of your cells for toxicity testing.

Get Best Practices
Fluorescent orange and black primary bronchial tracheal epithelial cells.

ATCC Human Bronchial Tracheal Epithelial Cells

ATCC investigated the properties of primary HBECs and validated them as an in vitro model to improve respiratory studies.

Download the Application Note

Toxicology products

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