Modeling, Screening, Characterizing
Get started on the path to success in the preclinical arena with our complete solution of continuous cell lines, growth reagents, and cell viability assays.
Preclinical Toxicology PK Metabolism
Need a functional model to explore the ADME of a new chemical entity? Discover how neurological and renal cell models can support your metabolic stability, metabolite identification, and drug-drug interaction assays.
Pharmacology, Exploratory, Toxicology
Do you need a model that reflects true physiology? Get started with differentiated iPSCs and primary and hTERT-immortalized primary cells.
Cell Lines for Toxicology
Authenticated ATCC cells ensure your toxicology results are accurate. Explore our complete set of solutions today!
Models for the preliminary stages of toxicity testing
Modeling, screening, and characterizing candidate therapeutics happens at a rapid pace. Drug development scientists need to be able to screen an astronomical number of these biological and chemical entities to eliminate all but a few strong candidates for further interrogation. ATCC can get you started on the path to success in the preclinical arena with our complete solution of continuous cell lines, growth reagents, and cell viability assays.
- Continuous Cell Lines – Eliminate large numbers of chemical entities by using high- throughput screening. ATCC offers authenticated cell lines from all physiological systems of the body.
- Cell Growth Reagents – We offer uniquely formulated media, sera, and reagents to virtually guarantee successful cell culture.
- Cell Viability Assays – Track the effects of a prospective compound by using an ATCC Cell Proliferation Assay kit. These assays are convenient, easy-to-use, and measure viability and growth.
Browse our cell lines for toxicity testing
Primary Hepatocytes and Hepatic Cells
Liver toxicity is one of the leading causes of approved drugs being removed from the market. Support your metabolic stability, metabolite identification, and drug-drug interaction assays today with fully authenticated primary human hepatocytes and hepatic cell lines and rule out possible toxicities faster.
Order hepatic cell linesRenal Cell Lines
The kidneys are responsible for excreting exogenous compounds. Immortalized kidney cell lines are among the most widely used in vitro models for initial toxicity testing due to their high proliferative capacity. Rule out possible toxicities faster by using ATCC authenticated renal cell lines.
Explore kidney cellsSkin Cell Lines
Irritation and destruction of the epidermis are red flags to scientists working on topically applied preparations. ATCC offers a wide selection of dermal cell lines, such as keratinocytes, melanocytes, and dermal fibroblasts to study the effect of cosmetics, dyes, and other chemical entities on skin.
Order skin cell linesAirway Cell Lines
Cardiovascular Cell Lines
A large proportion of drugs fail in early clinical phases due to cardiovascular problems. To help researchers screen compounds that may be toxic to the cardiovascular system, ATCC provides a wide variety of endothelial and smooth muscle continuous cell lines derived from the heart, aorta, arteries, veins, and capillaries.
Order cardiovascular cellsNeural Cell Lines
Neural tissue-derived cell lines provide a proliferating, easy-to-grow solution for identifying potential neurotoxicities in novel chemical entities. To quickly screen for toxic effects on the airway, ATCC provides a wide variety of continuous neural cell lines of multiple species such as neurons and the supporting cells of the central and peripheral nervous system.
Explore neural cell linesWatch our webinar to learn how hTERT-immortalized cells can improve your toxicity assays
Featured resources
Cell Culture Fundamentals: Your Questions Answered
The successful cultivation of cells is critical for performing cell-based assays. Get tips and techniques for initiation, expansion, authentication, and cryopreservation.
Watch the VideoAnimal Cell Culture Guide
This guide contains general technical information for working with animal cells in culture, including media, subculturing, cryopreservation, and contamination.
Learn MorehTERT Cell Culture Guide
This guide provides researchers with specific protocols for culturing a variety of hTERT-immortalized cell types.
See the GuidePrimary Cell Culture Guide
Access detailed information on the best practices of culturing and maintaining these versatile cells.
Discover NowStem Cell Culture Guide
Get this essential culture guide to help in your stem cell research
Download the GuideCryopreservation
Get the cryoprotectants and tools you need to ensure maximum viability of cells in cell culture.
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