Pancreatic Cancer Organoid Panel, CDKN2A

These pancreatic organoids retain native tumor morphology and cellular heterogeneity, enabling researchers to investigate pancreatic cancer biology and therapeutic vulnerabilities with greater clinical relevance. Key applications of this organoid panel include, but are not limited to:

• Drug Screening & Sensitivity Testing
• Mechanistic Studies of Pancreatic Cancer Progression
• Biomarker Discovery & Validation
• Comparative Studies Across Pancreatic Cancer Subtype
• Preclinical Modeling for Novel Therapeutics

Human-relevant patient-derived pancreatic cancer organoids present an opportunity to evaluate Cyclin‑dependent kinase inhibitor 2A (CDKN2A), which is a tumor suppressor gene frequently inactivated by somatic mutations across many cancers, including melanoma, gastrointestinal, and pancreatic malignancies, and germline mutations in CDKN2A confer inherited cancer risk. Despite its high prevalence, there are currently no approved therapies that directly target CDKN2A mutations. Adoptive cell therapy, particularly T‑cell receptor (TCR)–engineered T cell approaches, offers a promising strategy by targeting CDKN2A‑derived neoantigens presented by common HLA alleles—neoantigens absent from healthy cells—enabling selective tumor targeting. Both autologous and off‑the‑shelf allogeneic TCR‑engineered T cell therapies, alone or in combination with other immunotherapies, have the potential to provide broadly applicable, mutation‑specific treatments for patients with CDKN2A‑mutant cancers.

A panel of 3 pancreatic cancer organoids with varying degrees of genetic complexity. They have genomic mutation of Cyclin‑dependent kinase inhibitor 2A (CDKN2A).

Corresponding clinical data and genomic information can be accessed through the Human Cancer Models Initiative (HCMI) searchable catalog via the links below:

https://ocg.cancer.gov/programs/hcmi/resources

https://portal.gdc.cancer.gov/

Information associated with the individual pancreatic cancer organoids within the panel can be accessed via the links below:

https://hcmi-searchable-catalog.nci.nih.gov/model/HCM-BROD-0015-C25

https://hcmi-searchable-catalog.nci.nih.gov/model/HCM-CSHL-0090-C25

https://hcmi-searchable-catalog.nci.nih.gov/model/HCM-CSHL-0088-C25

Handling information including subculturing, cryopreservation, and associated media and reagents information can be found under the individual product pages for the organoids included in this panel: Linked below:

HCM-BROD-0015-C25, ATCC PDM-110

HCM-CSHL-0090-C25, ATCC PDM-37

HCM-CSHL-0088-C25, ATCC PDM-35

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