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Human Cancer Models Initiative

Green and blue conditionally reprogrammed organoid cells.

Revolutionizing cancer research with next-generation 2-D and 3-D patient-derived cancer models

The Human Cancer Models Initiative (HCMI) is an international consortium that is dedicated to generating novel human tumor-derived culture models with associated genomic and clinical data. The HCMI consortium comprises funding agencies and cancer model development institutions. The consortium's funding agencies include the National Cancer Institute (NCI), Cancer Research UK (CRUK), Hubrecht Organoid Technology (HUB), and Wellcome Sanger Institute (WSI). NCI-funded model development institutions include the Broad Institute and the Cold Spring Harbor Laboratory. CRUK and WSI co-fund organoid development in the United Kingdom; CRUK provides the patient samples, while WSI derives and sequences the organoid models. The foundation HUB is a Netherlands-based not-for-profit organization that derives and sequences organoid models. ATCC was selected as the sole distributor for the HCMI models. The generating institutions deposit the models into ATCC, where they are authenticated, expanded, preserved, and made available for global distribution. The HCMI model data are available from the NCI as a resource to the research community.

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HCMI Searchable Catalog

The HCMI Searchable Catalog is available from the NCI as a resource to the research community. Users are able to query the continuously updated resource and access information on all the available next-generation models developed by HCMI. Within the catalog, users can search by patient demographics, tumor, and model elements including diagnosis age, sex, treatment information, clinical tumor diagnosis, primary site, clinical stage, model type (eg, 3-D organoid, 2-D conditionally reprogrammed cells), and open-access masked somatic MAF variants, etc. ATCC is the designated sole  distributor for the models. and researchers can acquire the models directly from ATCC.

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Patient-derived cancer models

ATCC is excited to provide the HCMI models, which include both common as well as rare and understudied examples of cancer from numerous tissues. These HCMI models are valuable tools to study cancer, identify and target novel therapies, and facilitate translational cancer research. To enhance their clinical relevance, the sequence data and patient clinical information for each model is available to the research community.

Features of 2-D and 3-D HCMI models:

  • All models are human patient-derived
  • Diverse genetic backgrounds
  • Advanced models such as organoids
  • Clinical and sequencing data available via the HCMI portal
  • Models from primary, metastatic, and recurrent cancer
  • Rare and pediatric cancers included
  • Model-specific, easy-to-follow culturing protocols

Patient-derived cancer models of the following physiological systems will be available:

  • Circulatory System
  • Digestive System
  • Excretory System
  • Integumentary System
  • Musculo-skeletal System
  • Nervous System
  • Reproductive System
  • Respiratory System
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Organoids are game changers for cancer research

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Download a product list of current HCMI models

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Human Cancer Model Initiative

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