In collaboration with the Human Cancer Models Initiative (HCMI), ATCC offers scientists a wide variety of next-generation 3-D patient-derived in vitro cancer models, including organoids.
Organoids are complex, self-organizing microtissues grown embedded within 3-D extracellular matrix. Organoids may contain multiple differentiated cell types, exhibit cellular polarization, and often possess a central lumen and other in vivo–like architectural features. Organoids are capable of long-term expansion in culture while remaining phenotypically and genetically stable. Primary patient-derived organoids have been described for various tissues, healthy and cancerous, including colon, intestine, stomach, breast, esophagus, lung, liver, prostate, and pancreas. Organoids are invaluable preclinical models for studying cancer and offer many advantages over existing human or non-human animal cancer models.
Bioproduction of organoids in support of HCMI
Organoid culture represents a significant divergence from typical two-dimensional monolayer culture of continuous cell lines. The research results show that these next-generation in vitro models are suitable for larger-scale bioproduction. This is vital to ensure the widespread availability of these models within the research community to facilitate applications like preclinical drug discovery and basic cancer research.
Culturing organoids can be intimidating. To help researchers get their organoids growing, ATCC scientists created educational materials that contains everything you need to know about the initiation, expansion, and cryopreservation of organoids in embedded 3-D culture. Watch our instructional video on demand, or download the comprehensive organoid culture guide.Learn More