Discover How Credible Leads to Incredible
Scientific advancements are critical for unlocking incredible breakthroughs in global health. Yet, life science research is faced with a credibility crisis that restrains progress. At ATCC, we believe that credible leads to incredible. That's why ATCC is committed to addressing some of the major challenges affecting credibility in biological research. We pledge to empower scientists with cutting-edge authentication techniques, advanced biological models, and essential resources needed to accelerate innovative research. Watch our video to learn more about our pledge to improve reproducibility in life science research.
Advancing Authentication - A Case for Credibility in Science
Cell lines are the workhorse of biomedical research, so having the right cell model is critical. However, many laboratories are still unaware of the degree of how big of a problem cell line cross-contamination and misidentification are. Watch the video to learn more about this issue and to explore which methods and techniques cell biology experts are using to ensure the quality and authenticity of their models.
Tutorial: Thawing, Culturing, and Cryopreserving Human Organoids
The currently available preclinical cancer models are often inadequate for studying cancer biology, developing personalized therapeutics, and identifying unique biomarkers. To address this deficit, ATCC has collaborated with the Human Cancer Model Initiative (HCMI) to provide over 200 patient-derived models, including organoids. Watch our tutorial to learn more about next-generation organoid models and to explore step-by-step instructions that thoroughly demonstrate the process of thawing, expanding, and cryopreserving them.
Organoid Tumor Antigens as Drug Targets: Look Inside!
Organoids are game changers for cancer research. In this animated video, we take a look at organoids from different angles. Initially we see spherical organoids embedded in a gel matrix. Then a cross section of one organoid is revealed along with immunofluorescence staining of several markers. Next, the cross section of the plasma membrane comes into view, exposing tumor antigens such as PD-L1 and PD-l2 on the top, followed by intracellular signaling molecules underneath, such as RAS, FYN, SRC, PTEN, and others. Watch the video to see an organoid and how their tumor antigens can be used as drug targets.
Next-generation Biological Models: Revolutionizing Cancer Research
Cancer is not just one disease, it is thousands. To fully understand the various types of cancer, researchers need access to advanced biological models that accurately represent the complexity of human tumors. To meet this need, ATCC has collaborated with the Human Cancer Models Initiative (HCMI) to provide scientists with a wide variety of next-generation 2-D and 3-D patient-derived in vitro cancer models. Watch our video to learn more about these next-generation models and how they can be applied in your research.
Advanced Biological Models for Cancer Research
In vitro models have changed dramatically over the last several decades. New technologies have enabled the conditional reprogramming of cells and the development of organoids, which has allowed for the propagation of cancer models that better recapitulate the complexity of human tumors as compared to existing cell lines. Watch our video to learn more about these next-generation models and how they can be used to mimic the in vivo situation.
A Quest for Better Biological Models
The brain is the last great medical frontier. Over the past several decades, there has been a tremendous amount of research that has provided the basis for a better understanding of how the brain works. With this growing knowledge, neurological models have changed dramatically. Researchers now have access to advanced biological models such as induced pluripotent stem cells, neural progenitor cells, isogenic models, and organoids that better represent the cell types and tumors seen in the brain. Watch our video to learn more about these neurological models.
Learning from Zika: Preparing for the Next Outbreak
It takes the combined efforts of dedicated scientists to discover the treatments and diagnostic tools needed to keep humankind healthy and safe. That's why ATCC is committed to acquiring, authenticating, maintaining, and globally distributing clinically relevant pathogens to the dedicated scientists working toward preventing and containing the world’s most devastating epidemics. Watch our documentary to explore ATCC's role in the collection, authentication, and distribution of the viral strains used in a critical NIH study focused on containing the Zika crisis.
Discover How to Authenticate Your Cells in 3 Easy Steps
Have you had reproducibility issues in your experiments? Short-tandem repeat (STR) profiling of cell lines is an easy way to authenticate/confirm the identity of your cells. STR profiling aids in the detection of misidentified, cross-contaminated, or genetically drifted cells, which invalidate research results. Watch our video to learn more about STR profiling and how to get your cells authenticated in three easy steps.
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