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ATCC highly recommends that appropriate personal protective equipment is always used when handling vials. For cultures that require storage in liquid nitrogen, it is important to note that some vials may leak when submersed in liquid nitrogen and will slowly fill with liquid nitrogen. Upon thawing, the conversion of the liquid nitrogen back to its gas phase may result in the vial exploding or blowing off its cap with dangerous force creating flying debris. Unless necessary, ATCC recommends that these cultures be stored in the vapor phase of liquid nitrogen rather than submersed in liquid nitrogen.
This cell line may be used in the development of treatments and identifiable therapeutic targets for chordoma cancers
The Chordoma Foundation can offer financial assistance for the purchase of this cell line. Please contact [email protected] for more information.
UM-Chor1 is the first known human clival chordoma established. It exhibits chordoma-like characteristics and has molecular, genetic, and morphological features typical of chordoma. This cell line was established from a suprasellar lesion with solid, cystic, and hemorrhagic components. It extended along the clivus, and into the ethmoid sinuses. Chordoma is a rare slow growing tumor type, and UM-Chor1 is a relatively slow growing cell line. The cells express the transcription factor T (Brachyury) that is the most specific marker for chordoma. This cell line was accessioned with the support of the Chordoma Foundation, a nonprofit organization working to improve the lives of chordoma patients by accelerating research to develop effective treatments for the chordoma disease. This rare chordoma cell line can be a useful tool for studying the diversity of primary tumors of the spinal chord.
This cell line was accessioned with the support of the Chordoma Foundation, a non-profit organization working to improve the lives of chordoma patients by accelerating research to develop effective treatments for the chordoma disease.
To ensure the highest level of viability, thaw the vial and initiate the culture as soon as possible upon receipt. If upon arrival, continued storage of the frozen culture is necessary, it should be stored in liquid nitrogen vapor phase and not at -70°C. Storage at -70°C will result in loss of viability.
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Owen JH, et al. Establishment and characterization of two novel human chordoma cell lines. Annual Meeting of American Head and Neck Society 2014 Poster