Derivation
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This cell line was initiated on 2/8/95 from a patient with a significant family history of early-onset colon cancer as well as a sister with breast cancer. The cell line took 14 months to establish.
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Receptor Expression
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estrogen receptor progesterone receptor
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Genes Expressed
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Epithelial glycoprotein 2 (EGP2),cytokeratin 19
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Cellular Products
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Epithelial glycoprotein 2 (EGP2) cytokeratin 19
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Comments
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The tumor was classified as TNM stage IIB, grade 2, invasive ductal carcinoma with 4 out of 24 lymph node metastasis.
The cells are poorly differentiated.
The cells are negative for expression of Her2-neu but positive for expression of p53.
HCC1500 is positive for the epithelial cell specific marker Epithelial Glycoprotein 2 (EGP2) and for cytokeratin 19.
The cells are positive for expression of estrogen receptor (ER) and for expression of progesterone receptor (PR).
HCC1500 contains a homozygous deletion at 3p21.3.
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