FGFR Genetic Alteration Cell Panel

TCP-1034 ^™

Fibroblast Growth Factor Receptors (FGFRs), are transmembrane tyrosine kinase receptors that induce intracellular tyrosine kinase activity when bound to Fibroblast Growth Factor. FGFR plays crucial roles in development and cell growth. Upregulation of the FGF/FGFR signaling pathway leads to induction of mitogenic and survival signals, as well as promoting epithelial-mesenchymal transition, invasion and tumor angiogenesis. Amplification or activation of FGFR1 and FGFR2 genes has been linked to several cancer types such as lung cancer, breast cancer and gastric cancer.

The FGFR genetic alteration cell panel (ATCC TCP-1034) is composed of eight selected human tumor cell lines from common cancer types that carry various gene copy number amplification within the FGFR1 or FGFR2 genes. The FGFR1 or FGFR2 status of each cell line has been validated by ATCC. This panel is useful for FGFR pathway research and FGFR inhibitors anti-cancer drug discovery.

Components: ATCC HTB-23 MDA-MB-134-VI
ATCC CRL-2066 DMS 114
ATCC CCL-235 SW837
ATCC CCL-246 KG-1
ATCC CCL-247 HCT116
ATCC CRL-5974 SNU-16
ATCC HTB-103 KATO III
ATCC CRL-1739 AGS
Product format: Frozen
Shipping information: 8 vials
Storage conditions: Vapor phase of liquid nitrogen

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Documentation

Product sheet

Instructions for use

BSL 2

ATCC determines the biosafety level of a material based on our risk assessment as guided by the current edition of Biosafety in Microbiological and Biomedical Laboratories (BMBL), U.S. Department of Health and Human Services. It is your responsibility to understand the hazards associated with the material per your organization’s policies and procedures as well as any other applicable regulations as enforced by your local or national agencies.

Cells contain parainfluenza virus type 5 (HPIV-5)

ATCC highly recommends that appropriate personal protective equipment is always used when handling vials. For cultures that require storage in liquid nitrogen, it is important to note that some vials may leak when submersed in liquid nitrogen and will slowly fill with liquid nitrogen. Upon thawing, the conversion of the liquid nitrogen back to its gas phase may result in the vial exploding or blowing off its cap with dangerous force creating flying debris. Unless necessary, ATCC recommends that these cultures be stored in the vapor phase of liquid nitrogen rather than submersed in liquid nitrogen.

Required Products

These products are vital for the proper use of this item and have been confirmed as effective in supporting functionality. If you use alternative products, the quality and effectiveness of the item may be affected.

Leibovitz's L-15 Medium

30-2008

Iscove's Modified Dulbecco's Medium (IMDM)

30-2005

RPMI-1640 Medium

30-2001

F-12K Medium (Kaighn's Modification of Ham's F-12 Medium)

30-2004

General

Specific applications: This validated panel is composed of 8 select human cancer cell lines carrying various degrees of FGFR1 and FGFR2 amplification, and is useful for FGFR pathway research and for anti-cancer drug discovery.

Characteristics

Comments: Fibroblast Growth Factor Receptors (FGFRs), are transmembrane tyrosine kinase receptors that induce intracellular tyrosine kinase activity when bound to Fibroblast Growth Factor. FGFR plays crucial roles in development and cell growth. Upregulation of the FGF/FGFR signaling pathway leads to induction of mitogenic and survival signals, as well as promoting epithelial-mesenchymal transition, invasion and tumor angiogenesis. Amplification or activation of FGFR1 and FGFR2 genes has been linked to several cancer types such as lung cancer, breast cancer and gastric cancer.

The FGFR genetic alteration cell panel (ATCC TCP-1034) is composed of eight selected human tumor cell lines from common cancer types that carry various gene copy number amplification within the FGFR1 or FGFR2 genes. The FGFR1 or FGFR2 status of each cell line has been validated by ATCC. This panel is useful for FGFR pathway research and FGFR inhibitors anti-cancer drug discovery.

Legal disclaimers

Intended use

This product is intended for laboratory research use only. It is not intended for any animal or human therapeutic use, any human or animal consumption, or any diagnostic use.

Warranty

The product is provided 'AS IS' and the viability of ATCC^® products is warranted for 30 days from the date of shipment, provided that the customer has stored and handled the product according to the information included on the product information sheet, website, and Certificate of Analysis. For living cultures, ATCC lists the media formulation and reagents that have been found to be effective for the product. While other unspecified media and reagents may also produce satisfactory results, a change in the ATCC and/or depositor-recommended protocols may affect the recovery, growth, and/or function of the product. If an alternative medium formulation or reagent is used, the ATCC warranty for viability is no longer valid. Except as expressly set forth herein, no other warranties of any kind are provided, express or implied, including, but not limited to, any implied warranties of merchantability, fitness for a particular purpose, manufacture according to cGMP standards, typicality, safety, accuracy, and/or noninfringement.

Disclaimers

This product is intended for laboratory research use only. It is not intended for any animal or human therapeutic use, any human or animal consumption, or any diagnostic use. Any proposed commercial use is prohibited without a license from ATCC.

While ATCC uses reasonable efforts to include accurate and up-to-date information on this product sheet, ATCC makes no warranties or representations as to its accuracy. Citations from scientific literature and patents are provided for informational purposes only. ATCC does not warrant that such information has been confirmed to be accurate or complete and the customer bears the sole responsibility of confirming the accuracy and completeness of any such information.

This product is sent on the condition that the customer is responsible for and assumes all risk and responsibility in connection with the receipt, handling, storage, disposal, and use of the ATCC product including without limitation taking all appropriate safety and handling precautions to minimize health or environmental risk. As a condition of receiving the material, the customer agrees that any activity undertaken with the ATCC product and any progeny or modifications will be conducted in compliance with all applicable laws, regulations, and guidelines. This product is provided 'AS IS' with no representations or warranties whatsoever except as expressly set forth herein and in no event shall ATCC, its parents, subsidiaries, directors, officers, agents, employees, assigns, successors, and affiliates be liable for indirect, special, incidental, or consequential damages of any kind in connection with or arising out of the customer's use of the product. While reasonable effort is made to ensure authenticity and reliability of materials on deposit, ATCC is not liable for damages arising from the misidentification or misrepresentation of such materials.

Please see the material transfer agreement (MTA) for further details regarding the use of this product. The MTA is available at www.atcc.org.

Permits & Restrictions

For-profit Research Use License from MD Anderson Cancer Center

For-profit Organizations: For every order of this item, you must work directly with the contributor, MD Anderson Cancer Center to (i) negotiate a research-use license, and/or (ii) have the contributor provide authorization to ATCC to ship this item under your existing license. We cannot ship this item until we receive communication directly from MD Anderson Cancer Center that we are authorized to ship each order.

We are providing the following contact information, but this information may change without notice:
M.D. Anderson Cancer Center
Office of Technology Commercialization
Email: [email protected]

Once ATCC has received authorization from MD Anderson Cancer Center, your order will be reviewed, and this item will be released for shipment if all requirements are met. If you need assistance with your order, please contact our Customer Care team or your applicable distributor.

Import Permit for the State of Hawaii

If shipping to the U.S. state of Hawaii, you must provide either an import permit or documentation stating that an import permit is not required. We cannot ship this item until we receive this documentation. Contact the Hawaii Department of Agriculture (HDOA), Plant Industry Division, Plant Quarantine Branch to determine if an import permit is required.

MORE INFORMATION ABOUT PERMITS AND RESTRICTIONS

References

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