Reporter-labeled cell lines are invaluable research tools for studying gene expression and for screening cell lines. Some of the most commonly used reporter systems are those that induce a visually identifiable phenotype such as the emission of fluorescent or luminescent light or the production of a pigmented product.
Fluorescent reporters exhibit a fluorescent signal upon exposure to specific wavelengths of light; luminescent reporters use a luciferase enzyme to catalyze a reaction with its substrate, luciferin, to produce visible light; and chromogenic reporters employ an enzyme label that reacts with a substrate to produce a pigmented product.
Advantages of Reporter-labeled Cultures
Reporter systems have an array of applications in the basic and applied sciences. In biological research, reporter systems provide a measurable and distinguishable phenotype that can be applied in the analysis of:
To save you time and the expense associated with the development of reporter-labeled cells, ATCC has incorporated expression vectors harboring fluorescence, luciferase, or β-galactosidase reporter genes into a variety of clinically relevant cell lines.
These cell products have been thoroughly examined for:
- Reporter expression
- Vector stability
- Compatibility with detection technologies
- Growth rate
Epithelial-mesenchymal Transition Reporter Cells
Epithelial-mesenchymal transition (EMT) is a prominent biological process implicated in cancer metastasis. EMT has also been shown to have roles in many aspects of cancer initiation and progression, including tumorigenesis and drug resistance. Learn how our advanced in vitro models utilize EMT as a target for therapeutic research and development.EMT Products