Biological products include a wide range of complex substances such as vaccines, gene therapies, monoclonal antibodies, and recombinant therapeutic proteins. In contrast to most drugs that are chemically synthesized, biologics are manufactured in living cells. The demand for viruses and therapeutic macromolecules produced from mammalian cell culture is increasing along with the number of biopharmaceuticals that are currently in preclinical stage of development. In this regard, ATCC provides a variety of products that support the development and sterility testing of biologics.
- Virus and protein production – We offer both commonly used bioproduction cell lines for virus and protein manufacturing as well as STAT1 knockout models for enhanced virus production.
- Gene therapy development – ATCC provides a STAT1 BAX double knockout model for the enhanced production of adeno-associated viruses. We also offer internationally accepted viral reference materials that enable the standardization of quantification techniques when developing viral-vector-based gene therapies.
- Sterility testing – Our portfolio includes a variety of mycoplasma products and a PCR-based mycoplasma detection service that enable you to test your biologics for this common cell culture contaminant. We also provide reference strains recommended by the United States Pharmacopeia for evaluating biologics for sterility.
- Residual host cell DNA testing – ATCC and USP have formed a collaboration to provide highly characterized and pure genomic DNA analytical reference materials for validating the performance of molecular assays designed to detect and measure residual host cell genomic DNA.
Cell lines for enhanced virus production
Need high-titer viral stocks for vaccine or gene therapy development? Discover how STAT1 and BAX knockout cell lines can help. These cell lines can produce model clinical viruses and adeno-associated viruses at titers much higher than the parental cell lines, providing an efficient method for biopharmaceutical companies to increase production while reducing associated costs. Discover how these advanced biological models can be used in your vaccine and gene therapeutic development projects.
Learn more about these cell modelsExplore related products for biologics production
Mycoplasma testing
Mycoplasma contamination poses a major challenge for research laboratories and commercial facilities that employ cell lines in the development and manufacture of cell-derived biologics for medical use. Find the products and PCR-based service you need to test your materials for mycoplasma.
Test your cells for mycoplasma
Pharmaceutical testing
Microbial contamination is a serious issues currently facing the pharmaceutical industry as it can affect product quality and consumer safety. Don’t take chances on the quality of your products—insist on authenticated microbial reference strains from ATCC for your quality control testing.
Find quality control strainsResidual Host Cell DNA Testing
ATCC and USP have collaborated to develop genomic DNA analytical reference materials for use in detecting and measuring residual host cell genomic DNA. These quantitated materials provide effective high-quality controls to help mitigate risk during development and throughout the product lifecycle.
Explore the reference materials
Gene therapy development
When evaluating a novel viral-vector-based gene therapy, accurately determining dose and potency is essential for patient safety. ATCC supports this need by providing internationally accepted viral reference materials that enable the standardization of quantification techniques between organizations.
Explore viral reference materials
Vaccine development
The continual spread of deadly pathogens necessitates the development of effective prevention methods. ATCC supports vaccine development efforts by providing cell lines for enhanced virus production, clinically relevant pathogenic strains, and purified pneumococcal polysaccharides.
Find vaccine development tools
Mycoplasma testing
Mycoplasma contamination poses a major challenge for research laboratories and commercial facilities that employ cell lines in the development and manufacture of cell-derived biologics for medical use. Find the products and PCR-based service you need to test your materials for mycoplasma.
Test your cells for mycoplasma
Pharmaceutical testing
Microbial contamination is a serious issues currently facing the pharmaceutical industry as it can affect product quality and consumer safety. Don’t take chances on the quality of your products—insist on authenticated microbial reference strains from ATCC for your quality control testing.
Find quality control strainsResidual Host Cell DNA Testing
ATCC and USP have collaborated to develop genomic DNA analytical reference materials for use in detecting and measuring residual host cell genomic DNA. These quantitated materials provide effective high-quality controls to help mitigate risk during development and throughout the product lifecycle.
Explore the reference materials
Gene therapy development
When evaluating a novel viral-vector-based gene therapy, accurately determining dose and potency is essential for patient safety. ATCC supports this need by providing internationally accepted viral reference materials that enable the standardization of quantification techniques between organizations.
Explore viral reference materials
Vaccine development
The continual spread of deadly pathogens necessitates the development of effective prevention methods. ATCC supports vaccine development efforts by providing cell lines for enhanced virus production, clinically relevant pathogenic strains, and purified pneumococcal polysaccharides.
Find vaccine development tools1 / 2
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