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Vaccine Development

Clear vials sealed with silver caps, one vial lying on its side being punctured by syringe.

Together we can prevent devastating epidemics

The continual spread of deadly pathogens coupled with the dwindling supply of antimicrobial treatments necessitates the development of effective prevention methods. However, the development of novel vaccines can be challenged by the incredible variability between microbial strains and the limitations associated with the vaccine manufacturing process.

At ATCC, we believe that it takes the combined efforts of dedicated scientists throughout the world to discover the treatments needed to keep humankind healthy and safe. That’s why we are committed to providing researchers with the virus-producing cell lines, pathogenic microbial strains, and purified pneumococcal polysaccharides needed to support vaccine research and development.

Together, we can work toward preventing and containing the world’s most devastating epidemics. Browse our resources below to discover how ATCC can support your vaccine research.

Ebola virus budding from Vero cell red

Produce high-titer viral stocks

ATCC used cutting-edge CRISPR/Cas9 gene-editing technology to develop STAT1 knockout and STAT1/BAX double knockout cell lines capable of producing high-titer viral stocks. Discover how these advanced biological models can be used in your vaccine and gene therapeutic development projects.

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Vaccine development tools

Tangled ball of blue and yellow ebola virus tendrils.

Cell lines for virus production

Antiviral vaccines are essential for preventing epidemic disease; however, the production of these therapeutics is often limited by low-yielding manufacturing processes. To address this, ATCC used cutting-edge CRISPR/Cas9 gene-editing technology to develop STAT1 knockout cell lines capable of producing high-titer viral stocks. These STAT1-KO cell lines are not only good candidates for enhancing virus titers for vaccine development, but also useful tools to package lentiviral, adenoviral, and retroviral vectors for the delivery of DNA sequences into target cells for various applications such as gene therapy and cancer immunotherapy.

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Orange balls of Streptococcus bacteria.

Pneumococcal polysaccharides

Streptococcus pneumoniae is a major global health threat that is estimated to result in the death of one million children every year. While preventing the spread of this pathogenic bacterium through vaccination has been highly effective, the increasing rate of infections caused by non-vaccine serotypes presents new challenges toward containing the disease. To aid researchers in the analysis and prevention of pneumococcal disease, ATCC offers over 30 types of pneumococcal polysaccharides from various sources. These purified polysaccharides provide a unique tool for evaluating how effectively a vaccine can induce an immune response.

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Cluster of thin, pink, rod-shaped Mycobacterium tuberculosis.

The Need for Tuberculosis Reference Standards in Vaccine Development

Overall, there have been a number of factors attributed to the variations seen in BCG vaccine efficacy. Learn how manufacturers can come one step closer to improving BCG vaccine performance with a single consensus, biological standard that demonstrates high levels of protection when used in vaccine development.

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