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Streptomyces avermitilis (ex Burg et al.) Kim and Goodfellow (ATCC® 31267™)

Strain Designations: NRRL 8165 [JCM 5070, MA-4680, NCIMB 12804]  /  Type Strain: yes  /  Biosafety Level: 1

Deposited As Streptomyces avermitilis
Strain Designations NRRL 8165 [JCM 5070, MA-4680, NCIMB 12804]
Application
Produces avermectin avermectins, avermectin B(1)a C-076, and C-076 and derivatives.
Isolation
Soil, Ito City, Shizuoka Pref., Japan
Biosafety Level 1

Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country.
Product Format freeze-dried
Storage Conditions Frozen: -80°C or colder
Freeze-Dried: 2°C to 8°C
Live Culture: See Propagation Section
Disclosure This material is cited in a US or other Patent and may not be used to infringe the claims. Depending on the wishes of the Depositor, ATCC may be required to inform the Patent Depositor of the party to which the material was furnished. This material may not have been produced or characterized by ATCC.
Preceptrol® no
Genome Sequenced Strain

Streptomyces avermitilis MA-4680 DNA, complete genome.

Type Strain yes
Comments
Genome sequenced strain
Medium ATCC® Medium 184: Glucose asparagine agar
Growth Conditions
Temperature: 26°C
Atmosphere: Aerobic
Name of Depositor NRRL
U.S. Patent Number
Disclosure This material is cited in a US or other Patent and may not be used to infringe the claims. Depending on the wishes of the Depositor, ATCC may be required to inform the Patent Depositor of the party to which the material was furnished. This material may not have been produced or characterized by ATCC.
Special Collection NSF - Bacteriology
Chain of Custody
ATCC <-- NRRL <-- Merck & Co., Inc. MA-4680
Isolation
Soil, Ito City, Shizuoka Pref., Japan
References

Burg RW, et al. Avermectins, new family of potent anthelmintic agents: Producing organism and fermentation. Antimicrob. Agents Chemother. 15: 361-367, 1979. PubMed: 464561

Goegelman RT, et al. Novel C-076 compounds. US Patent 4,378,353 dated Mar 26 1983

Hafner EW, et al. Cultures for production of B avermectins. US Patent 5,565,359 dated Oct 15 1996

Ikeda H, et al. Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis. Nat. Biotechnol. 21: 526-531, 2003. PubMed: 12692562

Kim SB, Goodfellow M. Streptomyces avermitilis sp. nov., nom. rev., a taxonomic home for the avermectin-producing streptomycetes. Int. J. Syst. Evol. Microbiol. 52: 2011-2014, 2002. PubMed: 12508861

Miller TW, et al. Avermectins, new family of potent anthelmintic agents: Isolation and chromatographic properties. Antimicrob. Agents Chemother. 15: 368-371, 1979. PubMed: 464562

Ormond RE. 22-Hydroxy derivatives of C-076 compounds, pharmaceutical compositions and method of use. US Patent 4,412,991 dated Nov 1 1983

Cross References

Nucleotide (GenBank) : AY029771 Streptomyces avermitilis ribosomal protein S12 (rpsL) gene, complete cds.

Nucleotide (GenBank) : BA000030 Streptomyces avermitilis MA-4680 DNA, complete genome.