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1.800.638.6597

Streptomyces avermitilis (ex Burg et al.) Kim and Goodfellow (ATCC^® 31267^™)

Strain Designations: NRRL 8165 [JCM 5070, MA-4680, NCIMB 12804] / Type Strain: yes / Biosafety Level: 1

Streptomyces avermitilis (ex Burg et al.) Kim and Goodfellow ATCC^® 31267^™

freeze-dried

For-Profit: $365.00 Non-Profit: $310.25

Qty:

Permits and Restrictions	View Permits
Deposited As	Streptomyces avermitilis
Strain Designations	NRRL 8165 [JCM 5070, MA-4680, NCIMB 12804]
Application	Produces avermectin avermectins, avermectin B(1)a C-076, and C-076 and derivatives.
Isolation	Soil, Ito City, Shizuoka Pref., Japan
Biosafety Level	1 Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country.
Product Format	freeze-dried
Storage Conditions	Frozen: -80°C or colder Freeze-Dried: 2°C to 8°C Live Culture: See Propagation Section
Disclosure	This material is cited in a US or other Patent and may not be used to infringe the claims. Depending on the wishes of the Depositor, ATCC may be required to inform the Patent Depositor of the party to which the material was furnished. This material may not have been produced or characterized by ATCC.

Preceptrol®	no
Genome Sequenced Strain	Streptomyces avermitilis MA-4680 DNA, complete genome.
Type Strain	yes
Comments	Genome sequenced strain

Medium	ATCC^® Medium 184: Glucose asparagine agar
Growth Conditions	Temperature: 26°C Atmosphere: Aerobic

Name of Depositor	NRRL
U.S. Patent Number	4,378,353
Disclosure	This material is cited in a US or other Patent and may not be used to infringe the claims. Depending on the wishes of the Depositor, ATCC may be required to inform the Patent Depositor of the party to which the material was furnished. This material may not have been produced or characterized by ATCC.
Special Collection	NSF - Bacteriology
Chain of Custody	ATCC <-- NRRL <-- Merck & Co., Inc. MA-4680
Isolation	Soil, Ito City, Shizuoka Pref., Japan
References	Burg RW, et al. Avermectins, new family of potent anthelmintic agents: Producing organism and fermentation. Antimicrob. Agents Chemother. 15: 361-367, 1979. PubMed: 464561 Goegelman RT, et al. Novel C-076 compounds. US Patent 4,378,353 dated Mar 26 1983 Hafner EW, et al. Cultures for production of B avermectins. US Patent 5,565,359 dated Oct 15 1996 Ikeda H, et al. Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis. Nat. Biotechnol. 21: 526-531, 2003. PubMed: 12692562 Kim SB, Goodfellow M. Streptomyces avermitilis sp. nov., nom. rev., a taxonomic home for the avermectin-producing streptomycetes. Int. J. Syst. Evol. Microbiol. 52: 2011-2014, 2002. PubMed: 12508861 Miller TW, et al. Avermectins, new family of potent anthelmintic agents: Isolation and chromatographic properties. Antimicrob. Agents Chemother. 15: 368-371, 1979. PubMed: 464562 Ormond RE. 22-Hydroxy derivatives of C-076 compounds, pharmaceutical compositions and method of use. US Patent 4,412,991 dated Nov 1 1983
Cross References	Nucleotide (GenBank) : AY029771 Streptomyces avermitilis ribosomal protein S12 (rpsL) gene, complete cds. Nucleotide (GenBank) : BA000030 Streptomyces avermitilis MA-4680 DNA, complete genome.

Permits	These permits may be required for shipping this product: Customers located in the state of Hawaii will need to contact the Hawaii Department of Agriculture to determine if an Import Permit is required. A copy of the permit or documentation that a permit is not required must be sent to ATCC in advance of shipment.
Basic Documentation	Product Sheet Certificate of Analysis SDS