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Red and blue hek 293 stained protein.

ATCC’s Toxicology Portfolio: Tools for Every Stage of Your Preclinical Drug Development Workstream Webinar

February 16, 2023, at 12:00 PM ET

Abstract

Cell-based toxicity assays require large numbers of biologically relevant cells for predictive, large-scale experiments. Primary cells immortalized by human telomerase demonstrate the growth characteristics of continuous cell lines without losing their physiological attributes. In this webinar ATCC scientists discuss the characteristics and utility of various respiratory, skin, and kidney models in toxicological assays. Additionally, the speakers will present data that demonstrates that these modified primary cells are effective tools that provide tissue-relevant results and reproducibility for any cell-based assay, including toxicology assays.

Key Points

  • hTERT-immortalized primary cells are comparable to primary cells regarding physiological relevance, but are able to avoid replicative senescence
  • Using well-characterized hTERT-immortalized cells, ATCC has created credible cell models for toxicological studies on the kidney, skin, and airway
  • Our data show that these modified primary cells are effective tools that provide tissue-relevant results and reproducibility for any cell-based assay, including toxicology assays

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Long, strands of fluorescent blue skin dermal fibroblast cells.

hTERT Gingival Fibroblast

hTERT-immortalized primary gingival fibroblasts with applications in compound screening and oral/gingival toxicity studies.

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Green and blue NuLi lung epithelial small airway cells.

hTERT Cell Culture Guide

This guide provides researchers with specific protocols for culturing a variety of hTERT-immortalized cell types.

See the Guide
Fluorescent microscopy image of renal proximal tubular epithelial cells showing red-stained cytoskeletal structures and blue-stained nuclei, illustrating cellular morphology.

RPTEC/TERT1 OAT1

RPTEC/TERT1-OAT1 expresses SLC transporter hOAT1(SLC22A6) and has applications in kidney research and transport studies.

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Green WI-38 primary lung fibroblast cell culture.

hTERT Lung Fibroblast

Lung fibroblasts that were immortalized via transfection with the catalytic subunit of the human telomerase gene.

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Microscopic image showing a dense cluster of small, long, thin, yellow and brown melanocyte cells with intricate patterns and structures.

hTERT-immortalized Dermal Melanocyte

Immortalized dermal melanocyte derived from normal skin tissue that has applications in cosmetic research and skin trauma.

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Microscopic image showing a dense cluster of small, long, thin, yellow and brown melanocyte cells with intricate patterns and structures.

Ker-CT

Foreskin keratinocyte immortalized by human telomerase and CDK4 using retroviral pBABE-puro hTERT and pSRalphaMSU expressing mouse CDK4.

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Microscopic image of a stained bronchial epithelial sample showing mucus-secreting goblet cells along the epithelial lining, indicated by red arrows. The sample is likely stained with PAS (Periodic Acid-Schiff) stain and viewed at 20x magnification.

Primary Human Bronchial/Tracheal Epithelial Cells (PCS-300-010)

Primary bronchial/tracheal epithelial cells grown in ATCC Airway Epithelial Cell Basal Media and Bronchial Epithelial Cell Growth Kit are ideal for studying a variety of respiratory diseases.

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Microscopic image of skeletal muscle tissue in transverse section, showing elongated, striated muscle fibers with multiple nuclei stained in blue.

Human Primary Skeletal Muscle Cells

Skeletal muscle cells provide an ideal culture model for the study of muscle cell biology, muscle tissue repair, and myotube development.

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Fluorescence microscopy image showing a dense cluster of vaginal epithelial cells with blue-stained nuclei and red-stained cytoplasm, captured at 20X magnification.

Human Primary Vaginal Epithelial Cells

Vaginal epithelial cells provide a useful model for cancer research, evaluating host-pathogen interactions, and screening novel drugs.

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Microscopic image showing fluorescent purple renal proximal tubular epithelial cells with blue-stained nuclei. The cells are densely packed and exhibit a vibrant purple fluorescence, indicating the presence of specific markers or stains. A scale bar at the bottom right indicates a length of 100 µm.

RPTEC/TERT1 OAT3

This hTERT-immortalized SLC transporter cell model stably expresses hOAT3(SLC22A8). It has applications in kidney drug toxicity screening.

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Fluorescent microscopy image of renal proximal tubular epithelial cells showing green-stained cytoskeletal structures and blue-stained nuclei, highlighting cell morphology and arrangement.

RPTEC/TERT1 OCT2

The RPTEC/TERT1 cell line stably expresses SLC transporter hOCT2(SLC22A2). This cell model can be used for kidney drug toxicity screening.

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