ATCC-DYR0530 Human Induced Pluripotent Stem (IPS) Cells
ATCC-DYR0530 Human Induced Pluripotent Stem Cells (iPSCs) were derived from adult dermal fibroblasts obtained from a deceased 63 year-old donor who was diagnosed with Parkinson's disease (as well as asthma and depression; same donor as ACS-1013™, ACS-1014™). The fibroblasts were reprogrammed by the expression of OCT4, SOX2, KLF4 and MYC gene sequences using retroviral transduction. This cell line provides a unique model system for better understanding the molecular pathology associated with Parkinson's disease. The availability of ACS-1012™, ACS-1013™ and ACS-1014™ provide a set of iPSCs that allow a side-by-side comparison of various reprogramming methods (episomal plasmid, retrovirus and Sendai virus) on iPSC performance.