Acremonium chrysogenum (Thirumalachar et Sukapure) Gams, anamorph (ATCC® 14553)

Strain Designations: 8650  /  Product Format: freeze-dried

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Deposited As Cephalosporium sp.
Strain Designations 8650
produces cephalosporin C
produces cephalosporins
produces deacetoxycephalosporin C
produces penicillin
transformation host
produces: arthospore-inducing substances for production of cephalosporin C
Biosafety Level 1

Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country.

Product Format freeze-dried
Type Strain no
Preceptrol® no
transformation using a vector without bacterial DNA
Carries plasmid pAC1 for preparing a hybrid vector which promotes the biosynthesis of beta-lactam antibiotics
polymorphic karyotype
Medium ATCC® Medium 335: Potato carrot agar
Growth Conditions
Temperature: 24.0°C
Name of Depositor RC Godner
U.S. Patent Number
U.S. Patent
Disclosure This material is cited in a US or other Patent and may not be used to infringe the claims. Depending on the wishes of the Depositor, ATCC may be required to inform the Patent Depositor of the party to which the material was furnished.
Mutant of ATCC 11550
Cross References

Nucleotide (GenBank) : X72789 beta-tubulin gene


Kelly BK, et al. Production of cephalosporin C. US Patent 3,082,155 dated Mar 19 1963

Nakao Y, et al. Production of deacetoxycephalosporin C. US Patent 3,979,260 dated Sep 7 1976

Katamoto K, et al. Method for separating cephalosporins. US Patent 4,535,155 dated Aug 13 1985

Esser K, Minuth W. Plasmid pAC 1, a process for obtaining it and its use. US Patent 4,506,014 dated Mar 19 1985

Walz M, Kuck U. Polymorphic karyotypes in related Acremonium strains. Curr Genet 19: 73-76, 1991. PubMed: 1676616

Nowak C, Kuck U. Development of an homologous transformation system for Acremonium chrysogenum based on the beta-tubulin gene. Curr. Genet. 25: 34-40, 1994. PubMed: 8082163

Menne S, et al. Expression studies with the bidirectional pcbAB-pcbC promoter region from Acremonium chrysogenum using reporter gene fusions. Appl. Microbiol. Biotechnol. 42: 57-66, 1994. PubMed: 7765820

Nowak C, et al. DNA-mediated transformation of a fungus employing a vector devoid of bacterial DNA sequences. Appl. Microbiol. Biotechnol. 43: 1077-1081, 1995. PubMed: 8590659

Shirafuji H, et al. Accumulation of tripeptide derivatives by mutants of Cephalosporium acremonium. Agric. Biol. Chem. 43: 155-160, 1979.

Natsume M, Marumo S. Arthrospore-inducing substances from Acremonium chrysogenum which stimulate cephalosporin C production. Agric. Biol. Chem. 48: 567-569, 1984.

Huber FM, Redstone MO. Changes in the fatty acids of Cephalosporium acremonium Corda and its growth medium. Can. J. Microbiol. 13: 332-334, 1969.

Lemke PA, Nash CH. Mutations that affect antibiotic synthesis by Cephalosporium acremonium. Can. J. Microbiol. 18: 255-259, 1972. PubMed: 4336241

Queener SW, et al. Glutamate dehydrogenase specific activity and cephalosporin C synthesis in the M8650 series of Cephalosporium acremonium mutants. Antimicrob. Agents Chemother. 7: 646-651, 1975. PubMed: 1170808

Notice: Necessary PermitsPermits

These permits may be required for shipping this product:

  • Customers located in the state of Hawaii will need to contact the Hawaii Department of Agriculture to determine if an Import Permit is required. A copy of the permit or documentation that a permit is not required must be sent to ATCC in advance of shipment.
Basic Documentation