Enable Renal ADME and Pharmaco-kinetics Studies Using Solute Carrier Transporter Cells WebinarFebruary 23, 2023, at 12:00 PM ET
When developing cell based assays many toxicologists encounter challenges such as obtaining cells with high biological relevance and enough proliferative capacity to support the throughput of the assay without introducing cell variability. Additionally, while kidney membrane transporters are key to drug disposition and renal clearance, many of the current renal models lose the expression of organic anion transporter (OAT) 1 and 3 and organic cation transporter (OCT) 2 in culture. To address these issues, ATCC scientists have created physiologically relevant transporter cell models using hTERT-immortalized primary renal proximal tubule epithelial cells (RPTEC) that stably overexpress the OAT1, OCT2, or OAT3 gene. Join this webinar to see data indicating that these cell lines are provide tissue-relevant results, improved consistency over time, and predictability for clinical trials.
- There is a lack of in vitro models that durably and correctly recapitulate kidney physiology
- ATCC has created kidney cell models using a well characterized hTERT-immortalized RPTEC that stably overexpress the OAT1, OCT2, or OAT3 gene
- hTERT-immortalized, solute carrier protein-expressing RPTEC provide a predictive means of monitoring renal organic compound transport and toxicity