Due to high demand, this product is limited to 20 per organization per 60 days.
This isolate is lineage AY.24 (Pango v.3.1.14 2021-09-28), Delta (B.1.617.2-like) (Scorpio), and GISIAD clade GK using Phylogenetic Assignment of Named Global Outbreak lineages (PANGO) tool. Due to the dynamic nature of lineage determination using PANGO, discrepancies may exist between vial labels and the current lineage assignment.
The complete genome of the clinical isolate of SARS-CoV-2, hCoV-19/USA/MD-HP05285/2021 has been sequenced (GISAID: EPI_ISL_2103264). The following mutations are present in the clinical isolate: Spike D614G, Spike D950N, Spike L452R, Spike P681R, Spike T19R, Spike T478K, M (Membrane protein) I82T, N (Nucleocapsid) D63G, N D377Y, NS3 S26L, NSP3 (Non-structural protein 3) P822L, NSP4 (Non-structural protein 4) A446V, NSP6 (Non-structural protein 6) T181I, NSP6 V149A, NSP10 (Non-structural protein 10) L133F, NSP12 (Non-structural protein 12) G671S, NSP12 P323L, NSP13 (Non-structural protein 13) P77L. It was labelled as VOC Delta GK/478K.V1 (B.1.617.2+AY.x), first detected in India by the World Health Organization (WHO).
This product is a preparation of Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) strain USA/MD-HP05285/2021 that has been inactivated by heating at 65° for 30 minutes and is therefore unable to replicate.
The long-term stability of this preparation is not known at this time. It is recommended that users confirm the activity of the product if not used within three months of receipt.