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Monoclonal Anti-Zika virus envelope protein, clone ZV-16 (Immunoglobin G Mouse)

VR-1866

Product category
Viruses
Product type
Antibody
Antibody class
IgG2cκ
Applications
Infectious disease research
Vector-borne disease research
Zoonotic disease research
Volume
100 μL
Product format
Frozen
Shipping information
Purified monoclonal antibody in PBS, pH 7.4. The concentration, expressed as mg per mL, is shown on the Certificate of Analysis for each lot.
Storage conditions
-20°C or colder
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Price: $567.00 ea
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Biosafety Icon BSL 1

ATCC determines the biosafety level of a material based on our risk assessment as guided by the current edition of Biosafety in Microbiological and Biomedical Laboratories (BMBL), U.S. Department of Health and Human Services. It is your responsibility to understand the hazards associated with the material per your organization’s policies and procedures as well as any other applicable regulations as enforced by your local or national agencies.

Detailed product information

General

Specific applications
Emerging infectious disease research
Vector-borne disease research
Material development
Mouse monoclonal antibody prepared against the envelope (E) glycoprotein of Zika virus (ZIKV) was purified from ascites fluid by protein G affinity chromatography. Ascites formation was induced by injecting approximately 2.5 x 106 cultured hybridoma clone ZV-16 cells into the peritoneal cavities of pristine-primed mice. The B cell hybridoma was generated by the fusion of P3X6 Ag 8.6.5.3 mouse myeloma cells with immunized mouse splenocytes. The ZV-16 antibody specifically recognizes the E glycoprotein, is non-neutralizing, and does not cross-react with Dengue, Japanese encephalitis, or West Nile viruses.

Characteristics

Comments
ATCC® VR-1866™ specifically recognizes ZIKV-infected cells in indirect immunofluorescence assays. The clone ZV-16 antibody is also reported to function in ELISA and in western blot assays performed under non-reducing conditions.

History

Depositors
MS Diamond, Washington University School of Medicine
Chain of custody
ATVC <-- MS Diamond, Washington University School of Medicine

Legal disclaimers

Intended use
This product is intended for laboratory research use only. It is not intended for any animal or human therapeutic use, any human or animal consumption, or any diagnostic use.
Warranty

The product is provided 'AS IS' and the viability of ATCC® products is warranted for 30 days from the date of shipment, provided that the customer has stored and handled the product according to the information included on the product information sheet, website, and Certificate of Analysis. For living cultures, ATCC lists the media formulation and reagents that have been found to be effective for the product. While other unspecified media and reagents may also produce satisfactory results, a change in the ATCC and/or depositor-recommended protocols may affect the recovery, growth, and/or function of the product. If an alternative medium formulation or reagent is used, the ATCC warranty for viability is no longer valid.  Except as expressly set forth herein, no other warranties of any kind are provided, express or implied, including, but not limited to, any implied warranties of merchantability, fitness for a particular purpose, manufacture according to cGMP standards, typicality, safety, accuracy, and/or noninfringement.

Disclaimers

This product is intended for laboratory research use only. It is not intended for any animal or human therapeutic use, any human or animal consumption, or any diagnostic use. Any proposed commercial use is prohibited without a license from ATCC.

While ATCC uses reasonable efforts to include accurate and up-to-date information on this product sheet, ATCC makes no warranties or representations as to its accuracy. Citations from scientific literature and patents are provided for informational purposes only. ATCC does not warrant that such information has been confirmed to be accurate or complete and the customer bears the sole responsibility of confirming the accuracy and completeness of any such information.

This product is sent on the condition that the customer is responsible for and assumes all risk and responsibility in connection with the receipt, handling, storage, disposal, and use of the ATCC product including without limitation taking all appropriate safety and handling precautions to minimize health or environmental risk. As a condition of receiving the material, the customer agrees that any activity undertaken with the ATCC product and any progeny or modifications will be conducted in compliance with all applicable laws, regulations, and guidelines. This product is provided 'AS IS' with no representations or warranties whatsoever except as expressly set forth herein and in no event shall ATCC, its parents, subsidiaries, directors, officers, agents, employees, assigns, successors, and affiliates be liable for indirect, special, incidental, or consequential damages of any kind in connection with or arising out of the customer's use of the product. While reasonable effort is made to ensure authenticity and reliability of materials on deposit, ATCC is not liable for damages arising from the misidentification or misrepresentation of such materials.

Please see the material transfer agreement (MTA) for further details regarding the use of this product. The MTA is available at www.atcc.org.

Permits & Restrictions

For-profit Research-use License

For-profit organizations
For every order of this item, you must have a research-use and/or commercial-use license from the contributor. Please refer to the details in the “Permits and Restrictions” section of the product page for licensing information. We cannot ship this item until we receive this license or authorization directly from the contributor in the form of an email.

If sending the license to us, email the license to [email protected] with a reference to both your account and sales order numbers. Once either the license or authorization is received, your order will be reviewed, and this item will be released for shipment if all requirements are met. If you need assistance with your order, please contact our Customer Care team or your applicable distributor.

Import Permit for the State of Hawaii

If shipping to the U.S. state of Hawaii, you must provide either an import permit or documentation stating that an import permit is not required. We cannot ship this item until we receive this documentation. Contact the Hawaii Department of Agriculture (HDOA), Plant Industry Division, Plant Quarantine Branch to determine if an import permit is required.

This material is subject to the following restrictions in addition to those outlined in the ATCC Material Transfer Agreement:

  1. For-profit Recipients - must obtain a research use license prior to shipping.
  2. Commercial Use - all for-profit and non-profit Recipients must obtain a commercial use license prior to any Commercial Use.

Please contact Washington University in St. Louis at:

Washington University Office of Technology Management
Attn. Associate Director
Phone: 314-747-0920
Email:[email protected]

MORE INFORMATION ABOUT PERMITS AND RESTRICTIONS

References

Curated Citations

Miner JJ, et al. Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise. Cell 165(5): 1081-1091, 2016. PubMed: 27180225

Zhao H, et al. Structural Basis of Zika Virus-Specific Antibody Protection. Cell 166(4): 1016-1027, 2016. PubMed: 27475895

MS Diamond, personal communication

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