From Cell Selection to Safer Decisions: Human-Relevant Models for Predictive Toxicology

Selecting an appropriate human cell model is essential for generating reliable ADME, DMPK, toxicology, and safety data that support informed decision-making throughout drug development. In this webinar, we will examine the complementary roles of primary and hTERT-immortalized primary cells and discuss how these systems can be incorporated into toxicology testing strategies to address specific research objectives. Attendees will gain practical insights into model selection considerations that can enhance study relevance, improve translational outcomes, and help mitigate costly setbacks later in development. The presentation will also highlight experimental findings generated using primary human hepatocytes, peripheral blood mononuclear cells (PBMCs), and hTERT-immortalized primary renal proximal tubule epithelial cells (RPTECs). Following the presentation, participants are invited to join an interactive question-and-answer session.

Key Takeaways

• Best practices for selecting human cell models that support ADME, DMPK, and toxicity assessments
• Applications and advantages of primary hepatocytes, PBMCs, and hTERT-immortalized RPTECs across toxicology workflows
• How human-relevant in vitro systems can strengthen data interpretation, support decision-making, and reduce late-stage development risks