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Primary and hTERT-immortalized Cells: Physiologically Relevant Cell Models for Toxicological Assays

Purple and blue normal bronchial lung epithelial cells.


hTERT-immortalized primary cells exhibit the growth characteristics of continuous cell lines and retain the physiological attributes of primary cells. In this presentation, our experts discuss the characteristics of respiratory, ocular, cardiovascular, skin, reproductive, and kidney hTERT-immortalized primary cells, and their versatile utility in toxicological assays.

This presentation was an Exhibitor-Hosted Session. Although not an official part of the 2023 SOT Annual Meeting scientific program, its presentation was permitted by the Society.

Download the presentation to learn how primary and hTERT-immortalized cells can support your toxicology assays.



Sujoy Lahiri, headshot

Sujoy Lahiri, PhD

Lead Scientist, R&D, ATCC

Sujoy Lahiri, PhD, is an R&D scientist in ATCC. He leads the primary cell division, working on advanced cellular models using primary cells as well as expansion of ATCC’s primary cell portfolio. Dr. Lahiri has extensive knowledge in the field of toxicology and drug metabolism.

Carolina Lucchesi, headshot

Carolina Lucchesi, PhD

Principal Scientist, BioNexus, ATCC

Carolina Lucchesi is BioNexus Foundation Principal Scientist leading the Microphysiological Systems program at ATCC. Dr. Lucchesi received her PhD in Cellular and Molecular Biology from the University of Campinas in Brazil and has over 20 years of experience in Tissue Engineering and Organ-on-Chip technology. In her current role, Dr. Lucchesi leads the MPS program bringing new capabilities in the use of advanced 3D models and developing existing and new content to be applied in state-of-art technologies.

Brian Shapiro, headshot.

Brian Shapiro, PhD

Marketing Segment Manager, Oncology, ATCC

Brian A Shapiro, PhD, works to communicate the scientific breakthroughs of ATCC’s product development laboratories to the biomedical research community. Brian is the Executive Producer of ATCC's Podcast, Behind the Biology. Previously, he worked at Virginia Commonwealth University, where he investigated the role of pre-mRNA splicing in the multi-drug resistance of lung cancer. Dr. Shapiro attended the Medical College of Georgia, where his research focused on adrenal physiology as well as diseases of the epidermis.

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Products for toxicity testing

We provide the cells, media, and reagents needed to explore each step of the in vitro preclinical testing process—from modeling, screening, and characterization to exploratory toxicology, pharmacokinetics, and metabolism. Our growing portfolio of toxicology resources includes renal, neural, airway, and skin cell models for use in high-content screening, permeability assays, metabolic stability and survival studies, transport activity measurement, and more.

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Pink and green skin cancer cells.

hTERT-immortalized Primary Cells

Human telomerase reverse transcriptase (hTERT)–immortalized primary cells represent a breakthrough in cell biology research that combines the in vivo nature of primary cells with the traditional cell line's ability to survive continuously in vitro. ATCC genetically modified human primary cells so they exhibit the growth characteristics of a continuous cell line with extended proliferative capacity yet maintain the physiology of a primary cell.

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