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Mini Organs, Major Insights: Toxicology Goes 3-D

Green ECAD organoid cells.

Abstract

This talk spotlighted the shift toward animal-free toxicology through the use of 3-D cell cultures and microphysiological systems (MPS). These miniaturized organ models offer human-relevant insights into toxicity, enabling more ethical and predictive safety assessments. Attendees learned how these platforms are reshaping toxicology workflows and accelerating innovation without relying on animal testing. The session highlighted recent breakthroughs and practical applications in this evolving field.

Download the presentation to learn about the shift toward animal-free toxicology through the use of 3-D cell cultures and microphysiological systems (MPS)

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Presenter

Headshot of Carolina Lucchesi, PhD

Carolina Lucchesi, PhD

Principal Scientist, BioNexus, ATCC

Carolina Lucchesi is BioNexus Foundation Principal Scientist leading the Microphysiological Systems program at ATCC. Dr. Lucchesi received her PhD in Cellular and Molecular Biology from the University of Campinas in Brazil and has over 20 years of experience in Tissue Engineering and Organ-on-Chip technology. In her current role, Dr. Lucchesi leads the MPS program bringing new capabilities in the use of advanced 3D models and developing existing and new content to be applied in state-of-art technologies.

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Green, red, and blue organoid cells.

Organoids

During the drug discovery process, having access to models that recapitulate tumor properties is essential for predictive screening. ATCC provides patient-derived 3-D organoid models annotated with molecular and clinical data that represent a variety of healthy and cancerous tissues. These next-generation cancer models are capable of long-term expansion in culture while remaining phenotypically and genetically stable.

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Products for toxicity testing

We provide the cells, media, and reagents needed to explore each step of the in vitro preclinical testing process—from modeling, screening, and characterization to exploratory toxicology, pharmacokinetics, and metabolism. Our growing portfolio of toxicology resources includes renal, neural, airway, and skin cell models for use in high-content screening, permeability assays, metabolic stability and survival studies, transport activity measurement, and more.

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