Featuring Drs Fatah Kashanchi and Heather Branscome
Guests:
Fatah Kashanchi, PhD
Professor, George Mason University
Dr. Kashanchi is a tenured Professor at George Mason University (GMU) and the Director of the Laboratory of Molecular Virology. His research focuses on the mechanisms of viral gene expression and the dynamics of viral replication and host survival. He has published 220 peer reviewed manuscripts (h index = 59), served as an editorial board and reviewer for numerous scientific journals, and is a regular NIH study section member. Recently, Dr. Kashanchi's lab has concentrated on the roles of EVs and exosomes in viral infections. He received his Ph.D. in Microbiology at the University of Kansas and then moved to the National Cancer Institute prior to coming to GMU.
Heather Branscome, MS, PhD
Senior Scientist, ATCC
Dr. Heather Branscome is a Senior Scientist with ATCC. Throughout her 17-year career she has gained broad experience working in both academic and industry settings. She has extensive experience in cell and molecular biology and completed her graduate training in Biosciences from George Mason University. While at ATCC she has held positions in manufacturing, quality control, and technology transfer to support the production and qualification of cell lines and other critical biological reagents to support the scientific community. In her current role she manages a team of biologists to support the CDC’s International Reagent Resources (IRR) program, as well as other government contracts. Since 2018, she has played a key role in establishing and maintaining ATCC’s extracellular vesicle (EV) portfolio. In this role she was responsible for developing and validating large-scale EV manufacturing protocols and performing various EV biochemical and functional assays. Her current research is focused on advanced methods for EV purification, characterization of novel EV subtypes, and mechanistic studies of stem cell-derived EVs in different models of cellular repair. She currently serves as director and instructor for two local Bio-Trac® biotechnology training programs and maintains an active affiliation with George Mason University.
Show Notes:
In this episode Drs. Branscome and Kashanchi connect the dots between extracellular vesicles, virally infected cells, and cancer research. They then discuss how EV’s from stem cells may have a place in regenerative medicine and expound upon how one scientist's artifact can be another's pharmacological treasure.
Host:
David Yarmosh, MS
Lead Bioinformatician, ATCC
David Yarmosh is a lead bioinformatician in ATCC’s Sequencing and Bioinformatics Center. He’s a graduate of New York University’s Tandon School of Engineering. He has been working in large data aggregation and analysis since 2013 and microbial genomics with a focus on biosurveillance R&D efforts since 2016. David has led international training exercises in Peru and Senegal, sharing metagenomic analytical capabilities. His interests include genomics database construction, metadata collection, drug resistance mechanisms, bioinformatics standards, and machine learning. Since joining ATCC in 2020, David has worked extensively in SARS-CoV-2 classification, epidemiology, and genomics evaluation, including enhanced and uniform variant reporting. He has contributed more broadly to genomics reporting and analytical standardization and he has helped develop the podcast Behind the Biology, which he now hosts.
