Mycobacterium ulcerans MacCallum et al. (ATCC® 19423)

Strain Designations: NCTC 10417 [ATCC 14188, DSM 44154, RT, TMC 1617]  /  Type Strain: yes  /  Biosafety Level: 2

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Strain Designations NCTC 10417 [ATCC 14188, DSM 44154, RT, TMC 1617]
Isolation
Pus from leg ulcer
Biosafety Level 2

Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country.

Product Format frozen
Storage Conditions Frozen: -80°C or colder
Freeze-Dried: 2°C to 8°C
Live Culture: See Propagation Section
Preceptrol® no
Type Strain yes
Comments
This strain demonstrates reduced virulence in mice and does not produce mycolactone.
Name of Depositor NCTC
Special Collection NCRR Contract
Chain of Custody
ATCC <-- NCTC <-- G Buckle RT
Isolation
Pus from leg ulcer
References

Bentoucha A, et al. Activities of new macrolides and fluoroquinolones against Mycobacterium ulcerans infection in mice. Antimicrob. Agents Chemother. 45(11): 3109-3112, 2001. PubMed: 11600364

Bonicke R. Identification of mycobacteria by biochemical methods. Bull. Int. Union Tuberc. 32: 13-68, 1962.

Bull. Int. Union Tuberc. 30: 202, 1960.

Dega H, et al. Bactericidal activity of rifampin-amikacin against Mycobacterium ulcerans in mice. Antimicrob. Agents Chemother. 46(10): 3193-3196, 2002. PubMed: 12234844

Dega H, et al. Activities of several antimicrobials against Mycobacterium ulcerans infection in mice. Antimicrob. Agents Chemother. 44(9): 2367-2372, 2000. PubMed: 10952581

Fenner, F. The pathogenic behavior of Mycobacterium ulcerans and Mycobacterium balnei in the mouse and the developing chick embryo. Am. Rev. Tuberc. 73(5): 650-673, 1956.

Fenner F. The significance of the incubation period in infectious diseases. Med. J. Aust. 2: 813-818, 1950. PubMed: 14796139

Fenner F, Leach RH. Studies on Mycobacterium ulcerans. I. Serological relationship to other mycobacteria. Aust. J. Exp. Biol. Med. Sci. 30: 1-10, 1952.

Fenner F, Leach RH. Studies on Mycobacterium ulcerans. II. Cross reactivity in guinea pigs sensitized with Mycobacterium ulcerans and other mycobacteriium. Aust. J. Exp. Biol. Med. Sci. 30: 11-20, 1952.

George KM, et al. Mycolactone: a polyketide toxin from Mycobacterium ulcerans required for virulence. Science. 283(5403): 854-857, 1999. PubMed: 9933171

George KM, Pascopella L, Welty DM, Small PL. A Mycobacterium ulcerans toxin, mycolactone, causes apoptosis in guinea pig ulcers and tissue culture cells. Infect. Immun. 68(2): 877-883, 2000. PubMed: 10639458

Lapage SP, et al. Annotations from the FCTC on the list of type and reference strains of bacteria, Sneath and Skerman 1966. Int. J. Syst. Bacteriol. 17: 93-103, 1967.

MacCallum P. A new mycobacterial infection in man. I. Clinical aspects. J. Pathol. Bacteriol. 60: 93-122, 1948.

P Converse, personal communication

Skerman VB, et al. Approved lists of bacterial names. Int J Syst Bacteriol 30: 225-420, 1980.

Sneath PH, Skerman VB. A list of type and reference strains of bacteria. Int. J. Syst. Bacteriol. 16: 1-134, 1966.

Stinear TP, et al. Common evolutionary origin for the unstable virulence plasmid pMUM found in geographically diverse strains of Mycobacterium ulcerans. J. Bacteriol. 187(5): 1668-1676, 2005. PubMed: 15716437

Cross References

Nucleotide (GenBank) : AJ271681 Mycobacterium ulcerans tlyA gene for putative haemolysin.

Nucleotide (GenBank) : X99217 M.ulcerans internal transcribed spacer between 16S and 23S rRNA, genomic sequence.

Notice: Necessary PermitsPermits

These permits may be required for shipping this product:

  • Customers located in the state of Hawaii will need to contact the Hawaii Department of Agriculture to determine if an Import Permit is required. A copy of the permit or documentation that a permit is not required must be sent to ATCC in advance of shipment.
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