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GC-2.2 [GCS-2kb, lambda-EZZ-gamma3]


Homo sapiens, human
Clone type
Molecular biology
Product format
Mission Collection Item
This is a Mission Collection Item.


ATCC determines the biosafety level of a material based on our risk assessment as guided by the current edition of Biosafety in Microbiological and Biomedical Laboratories (BMBL), U.S. Department of Health and Human Services. It is your responsibility to understand the hazards associated with the material per your organization’s policies and procedures as well as any other applicable regulations as enforced by your local or national agencies.

Detailed product information


Specific applications
in another host, produces protein glucosidase, beta; acid Glucosidase, beta, acid, glucocerebrosidase


Restriction digests of the clone give the following sizes (kb): BamHI--4.0, 1.7, 1.0; EcoRI--4.4, 2.3; HindIII--4.6, 2.1; PvuII--3.7, 3.1; SalI--5.2, 1.6.
The insert includes the following restriction sites (kb from the 5' end): BamHI--0.027, 1.629; HindIII--0.231; ScaI--1.022; SalI--1.403.
Contains the complete coding sequence but lacks some of the 5' untranslated region. The coding sequences extend from nt 154 to 1709 of the published sequence.
Constructed from G5A-IY and ID9bb by taking advantage of the unique ScaI site in the region of overlap.
Mycoplasma contamination
Not detected

Vector information

Construct size (kb)

Insert information

Insert size (kb)
Type of DNA
Insert source
fibroblast WI-38 cell line
Insert tissue
fibroblast WI-38 cell line
Target gene
glucosidase, beta, acid
Gene product
glucosidase, beta; acid(Glucosidase, beta, acid, glucocerebrosidase) [GBA]

Handling information


E Beutler
Cross references
GenBank M11080
GenBank 169928

Legal disclaimers

Intended use
This product is intended for laboratory research use only. It is not intended for any animal or human therapeutic use, any human or animal consumption, or any diagnostic use.

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While ATCC uses reasonable efforts to include accurate and up-to-date information on this product sheet, ATCC makes no warranties or representations as to its accuracy. Citations from scientific literature and patents are provided for informational purposes only. ATCC does not warrant that such information has been confirmed to be accurate or complete and the customer bears the sole responsibility of confirming the accuracy and completeness of any such information.

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Permits & Restrictions

Import Permit for the State of Hawaii

If shipping to the U.S. state of Hawaii, you must provide either an import permit or documentation stating that an import permit is not required. We cannot ship this item until we receive this documentation. Contact the Hawaii Department of Agriculture (HDOA), Plant Industry Division, Plant Quarantine Branch to determine if an import permit is required.


Frequently Asked Questions


Curated Citations

Zimran A, et al. Linkage of the PvuII polymorphism with the common Jewish mutation for gaucher disease. Am. J. Hum. Genet. 46: 902-905, 1990. PubMed: 1971142

Dahl N, et al. Gaucher disease type III (Norrbottnian type) is caused by a single mutation in exon 10 of the glucocerebrosidase gene. Am. J. Hum. Genet. 47: 275-278, 1990. PubMed: 2378352

Sorge J, et al. Molecular cloning and nucleotide sequence of human glucocerebrosidase cDNA. Proc. Natl. Acad. Sci. USA 82: 7289-7293, 1985. PubMed: 3864160

Sorge J, et al. Correction. Proc. Natl. Acad. Sci. USA 83: 3567, 1986.

Sorge JA, et al. The human glucocerebrosidase gene has two funtional ATC initiator codons. Am. J. Hum. Genet. 41: 1016-1024, 1987. PubMed: 3687939

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