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lambdaEalphaTOU [lambdaTOUepsilonalpha, lambdaepsilonalphaTOU]


Homo sapiens, human
Clone type
Molecular biology
Product format
Shipping information
Rehydrate with TE
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ATCC determines the biosafety level of a material based on our risk assessment as guided by the current edition of Biosafety in Microbiological and Biomedical Laboratories (BMBL), U.S. Department of Health and Human Services. It is your responsibility to understand the hazards associated with the material per your organization’s policies and procedures as well as any other applicable regulations as enforced by your local or national agencies.

Detailed product information


Specific applications
A 0.6 kb XhoI/PstI fragment has been used as an alpha-specific probe.


Restriction digests of the clone give the following sizes (kb): BamHI--20.0, 16.0, 9.2, 2.8; EcoRI--20.0, 14.0, 9.2, 5.6; HindIII--23.0, 10.0, 7.8, 1.6; SacI--20.0, 9.2, 5.6, 4.6, 2.8, 2.5, 1.0 (doublet); XhoI--20.0, 14.0, 9.2, 5.0.
The insert contains the following restriction sites (approximate kb from the 5' BamHI site): BamHI--2.8, 18.7; HindIII--9.5, 17.5; EcoRI--13.7.
A 0.6 kb XhoI/PstI fragment has been used as an alpha-specific probe. The 3.8 kb EcoRI/HindIII fragment contains sequences characteristic of the A2m(2) allotype constant region and its 5' flanking sequences.
The 1.1 kb HindIII/BamHI fragment contains the transmembrane exon.
The insert begins just 5' to the sequences encoding the epsilon constant region and extend approximately 4.3 kb beyond the exons for the alpha chain.
Additional GenBank/EMBL accession numbers: M35287, M35291.
Mycoplasma contamination
Not detected

Vector information

Construct size (kb)

Insert information

Insert size (kb)
Type of DNA
Gene product
immunoglobulin epsilon [IGHE]


Cross references
GenBank J00221

Legal disclaimers

Intended use
This product is intended for laboratory research use only. It is not intended for any animal or human therapeutic use, any human or animal consumption, or any diagnostic use.

The product is provided 'AS IS' and the viability of ATCC® products is warranted for 30 days from the date of shipment, provided that the customer has stored and handled the product according to the information included on the product information sheet, website, and Certificate of Analysis. For living cultures, ATCC lists the media formulation and reagents that have been found to be effective for the product. While other unspecified media and reagents may also produce satisfactory results, a change in the ATCC and/or depositor-recommended protocols may affect the recovery, growth, and/or function of the product. If an alternative medium formulation or reagent is used, the ATCC warranty for viability is no longer valid.  Except as expressly set forth herein, no other warranties of any kind are provided, express or implied, including, but not limited to, any implied warranties of merchantability, fitness for a particular purpose, manufacture according to cGMP standards, typicality, safety, accuracy, and/or noninfringement.


This product is intended for laboratory research use only. It is not intended for any animal or human therapeutic use, any human or animal consumption, or any diagnostic use. Any proposed commercial use is prohibited without a license from ATCC.

While ATCC uses reasonable efforts to include accurate and up-to-date information on this product sheet, ATCC makes no warranties or representations as to its accuracy. Citations from scientific literature and patents are provided for informational purposes only. ATCC does not warrant that such information has been confirmed to be accurate or complete and the customer bears the sole responsibility of confirming the accuracy and completeness of any such information.

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Please see the material transfer agreement (MTA) for further details regarding the use of this product. The MTA is available at

Permits & Restrictions

Import Permit for the State of Hawaii

If shipping to the U.S. state of Hawaii, you must provide either an import permit or documentation stating that an import permit is not required. We cannot ship this item until we receive this documentation. Contact the Hawaii Department of Agriculture (HDOA), Plant Industry Division, Plant Quarantine Branch to determine if an import permit is required.


Frequently Asked Questions


Curated Citations

Lefranc MP, Rabbitts TH. Human immunoglobulin heavy chain A2 gene allotype determination by restriction fragment length polymorphism. Nucleic Acids Res. 12: 1303-1311, 1984. PubMed: 6322103

Bensmana M, Lefranc MP. Gene segments encoding membrane domains of the human immunoglobulin gamma 3 and alpha chains. Immunogenetics 32: 321-330, 1990. PubMed: 1979064

Flanagan JG, et al. Mechanisms of divergence and convergence of the human immunoglobulin alpha 1 and alpha 2 constant region gene sequences. Cell 36: 681-688, 1984. PubMed: 6421489

Bensmana M, et al. Sequence of the CH1 and hinge-CH2 exons of the human immunoglobulin IGHA2 A2m(2) allele: comparison with the nonallelic and allelic IGHA genes. Cytogenet. Cell Genet. 56: 128, 1991. PubMed: 1901541

Marie-Paule Lefranc, personal communication

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