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M27beta [M27B, M27Beta]


Homo sapiens, human
Clone type
Molecular biology
Product format
Shipping information
Rehydrate with TE
Mission Collection Item
This is a Mission Collection Item.


ATCC determines the biosafety level of a material based on our risk assessment as guided by the current edition of Biosafety in Microbiological and Biomedical Laboratories (BMBL), U.S. Department of Health and Human Services. It is your responsibility to understand the hazards associated with the material per your organization’s policies and procedures as well as any other applicable regulations as enforced by your local or national agencies.

Detailed product information


Specific applications
A stringency of 0.5 X SSC, 64 C was used routinely.


The insert contains 2 copies of a 2.2 kb insert containing the following restriction sites, separated by approximate kb: EcoRI- 0.4- HindIII- 0.1- BglII- 0.6- PvuII- 0.2- BglII- 0.9- EcoRI.
Restriction digests of the clone give the following sizes (kb): EcoRI--2.7, 2.4, 2.4; HindIII--4.55, 2.4, 0.55; PvuII--2.4, 2.4, 1.4, 1.3; BamHI--7.5; HindIII--7.5.
The EcoRI RFLP shows significant linkage to Wiskott-Aldrich Syndrome (theta = 0.00, Z = 10.19).
The 0.9 BglII/EcoRI fragment contains a 334 bp HaeIII/Sau3A fragment within which a deletion of about 3 kb occurred during cloning.
The 334 bp HaeIII/Sau3A fragment contains 3 complete copies and a partial copy of a 26 bp repeat which includes a 10 bp perfect inverted repeat separated by 3 nt.
EcoRI gives the best separation of alleles on 0.8% agarose gels. A stringency of 0.5 X SSC, 64 C was used routinely.
Mycoplasma contamination
Not detected

Vector information

Construct size (kb)

Insert information

Insert size (kb)
Type of DNA
Insert source
DNA from mouse/human MOG-T hybrid line (X only)
Insert tissue
DNA from mouse/human MOG-T hybrid line (X only)
Gene product
DNA Segment, single copy [DXS255]


IW Craig
Cross references
GenBank J03073
GenBank 167090

Legal disclaimers

Intended use
This product is intended for laboratory research use only. It is not intended for any animal or human therapeutic use, any human or animal consumption, or any diagnostic use.

The product is provided 'AS IS' and the viability of ATCC® products is warranted for 30 days from the date of shipment, provided that the customer has stored and handled the product according to the information included on the product information sheet, website, and Certificate of Analysis. For living cultures, ATCC lists the media formulation and reagents that have been found to be effective for the product. While other unspecified media and reagents may also produce satisfactory results, a change in the ATCC and/or depositor-recommended protocols may affect the recovery, growth, and/or function of the product. If an alternative medium formulation or reagent is used, the ATCC warranty for viability is no longer valid.  Except as expressly set forth herein, no other warranties of any kind are provided, express or implied, including, but not limited to, any implied warranties of merchantability, fitness for a particular purpose, manufacture according to cGMP standards, typicality, safety, accuracy, and/or noninfringement.


This product is intended for laboratory research use only. It is not intended for any animal or human therapeutic use, any human or animal consumption, or any diagnostic use. Any proposed commercial use is prohibited without a license from ATCC.

While ATCC uses reasonable efforts to include accurate and up-to-date information on this product sheet, ATCC makes no warranties or representations as to its accuracy. Citations from scientific literature and patents are provided for informational purposes only. ATCC does not warrant that such information has been confirmed to be accurate or complete and the customer bears the sole responsibility of confirming the accuracy and completeness of any such information.

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Please see the material transfer agreement (MTA) for further details regarding the use of this product. The MTA is available at

Permits & Restrictions

Import Permit for the State of Hawaii

If shipping to the U.S. state of Hawaii, you must provide either an import permit or documentation stating that an import permit is not required. We cannot ship this item until we receive this documentation. Contact the Hawaii Department of Agriculture (HDOA), Plant Industry Division, Plant Quarantine Branch to determine if an import permit is required.


Frequently Asked Questions


Curated Citations

Fraser NJ, et al. Multi-allelic RFLP for M27beta, an anonymous single copy genomic clone at Xp11.2-Xcen [HGM9 provisional no. DXS255]. Nucleic Acids Res. 15: 9616, 1987. PubMed: 2891116

Fraser NJ, et al. Isolation and characterization of a human variable copy number tandem repeat at Xcen-p11.2. Genomics 5: 144-148, 1989. PubMed: 2570025

Greer WL, et al. Linkage relationships of the Wiskott-Aldrich Syndrome to 10 loci in the pericentromeric region of the human X chromosome. Genomics 6: 568-571, 1990. PubMed: 2328995

Alitalo T, et al. Localization of the Aland Island Eye Disease locus to the pericentromeric region of the X chromosome by linkage analysis. Am. J. Hum. Genet. 48: 31-38, 1991. PubMed: 1985461

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