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pA10RP8 [pA10RP8]


Homo sapiens, human
Clone type
Molecular biology
Product format
Shipping information
Rehydrate with TE
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ATCC determines the biosafety level of a material based on our risk assessment as guided by the current edition of Biosafety in Microbiological and Biomedical Laboratories (BMBL), U.S. Department of Health and Human Services. It is your responsibility to understand the hazards associated with the material per your organization’s policies and procedures as well as any other applicable regulations as enforced by your local or national agencies.

Detailed product information


Restriction digests of the clone give the following sizes (kb): SacI--3.0, 1.35; SacI/PstI--3.0, 0.9, 0.4; PstI--3.8, 0.6; EcoRI--3.36, 0.38 (doublet), 0.3; HindIII--4.3.
There is tight linkage between multiple endocrine neoplasia type 2A (MEN2A) and D10Z1 (theta = 0, LOD score = 12.02).
Data for haplotypes formed by using the A and F morphs improved the LOD score for linkage between multiple endocrine neoplasia type 2A (MEN2A) and D10Z1 (theta = 0, LOD score = 14.06).
There is tight linkage between medullary thyroid carcinoma (MTC) with parathyroid tumors (PTs) and no pheochromocytomas (PHEOs) and D10Z1 (theta = 0, LOD score = 2.86).
The insert contains 4 EcoRI repeat units of 340 bp each. A SacI/PstI double digest should give fragments of 1.0 kb and 0.36 kb from the insert.
High stringency hybridization and washing conditions are necessary due to the repetitive nature of the probe.
The HinfI polymorphism detects the haplotypes at the following frequencies: F+G+ (0.5), F+G- (not seen), F-G+ (0.02), and F-G- (0.48).
Mycoplasma contamination
Not detected

Vector information

Construct size (kb)

Insert information

Insert size (kb)
Type of DNA
Gene product
DNA Segment, repetitive [D10Z1]
A2, B2, F2, G2, A2, B2, F2, G2, A1, B1, F1, G1, A1, B1, F1, G1

Legal disclaimers

Intended use
This product is intended for laboratory research use only. It is not intended for any animal or human therapeutic use, any human or animal consumption, or any diagnostic use.

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This product is intended for laboratory research use only. It is not intended for any animal or human therapeutic use, any human or animal consumption, or any diagnostic use. Any proposed commercial use is prohibited without a license from ATCC.

While ATCC uses reasonable efforts to include accurate and up-to-date information on this product sheet, ATCC makes no warranties or representations as to its accuracy. Citations from scientific literature and patents are provided for informational purposes only. ATCC does not warrant that such information has been confirmed to be accurate or complete and the customer bears the sole responsibility of confirming the accuracy and completeness of any such information.

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Permits & Restrictions

Import Permit for the State of Hawaii

If shipping to the U.S. state of Hawaii, you must provide either an import permit or documentation stating that an import permit is not required. We cannot ship this item until we receive this documentation. Contact the Hawaii Department of Agriculture (HDOA), Plant Industry Division, Plant Quarantine Branch to determine if an import permit is required.


Frequently Asked Questions


Curated Citations

Devilee P, et al. Chromosome-specific alpha satellite DNA: isolation and mapping of a polymorphic alphoid repeat from human chromosome 10. Genomics 3: 1-7, 1988. PubMed: 3220475

Wu JS, et al. The genetic defect in multiple endocrine neoplasia type 2A maps next to the centromere of chromosome 10. Am. J. Hum. Genet. 46: 624-630, 1990. PubMed: 1968709

Carson NL, Simpson NE. Two HinfI RFLPs detected by palphaRP8 at D10Z1. Nucleic Acids Res. 18: 1932, 1990. PubMed: 1970876

Carson NL, et al. The mutation for medullary thyroid carcinoma with parathyroid tumors (MTC with PTs) is closely linked to the centromeric region of chromosome 10. Am. J. Hum. Genet. 47: 946-951, 1990. PubMed: 1978560

Peter Devilee, personal communication

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