Homo sapiens, human
Clone type
Molecular biology
Product format
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Biosafety Icon BSL 1

ATCC determines the biosafety level of a material based on our risk assessment as guided by the current edition of Biosafety in Microbiological and Biomedical Laboratories (BMBL), U.S. Department of Health and Human Services. It is your responsibility to understand the hazards associated with the material per your organization’s policies and procedures as well as any other applicable regulations as enforced by your local or national agencies.

Detailed product information


Specific applications
produces protein murine leukemia viral (v-raf-1) oncogene homolog 1 Craf1 transforming gene, murine sarcoma 3611 oncogene 1, raf proto-oncogene serine/threonine protein kinase, v-raf-1 murine leukemia viral oncogene homolog 1, Oncogene RAF1


Restriction digests analyzed on agarose gels give the following sizes (kb): EcoRI--2.9, 2.7; HindIII--5.25, 0.55; BglII--5.7; XbaI--3.5, 2.2.
RAF1 shows linkage to Von Hippel-Lindau disease (VHL) with a LOD score of 4.38 with theta = 0.11.
Haplotype frequencies for the TaqI and BglI polymorphisms suggest only slight linkage disequilibrium between the two sites.
Significant linkage has been demonstrated to von Hippel-Lindau disease (theta = 0.0, z = 2.6).
Insert contains PvuII (2), HindII, SalI (2), StuI (3), SphI, BglII, EcoRV, and Xba sites.
Mycoplasma contamination
Not detected

Vector information

Construct size (kb)

Insert information

Insert size (kb)
Type of DNA
Insert source
fetal liver
Insert tissue
fetal liver
Target gene
murine leukemia viral (v-raf-1) oncogene homolog 1
Gene product
murine leukemia viral (v-raf-1) oncogene homolog 1( Craf1 transforming gene, murine sarcoma 3611 oncogene 1, raf proto-oncogene serine/threonine protein kinase, v-raf-1 murine leukemia viral oncogene homolog 1, Oncogene RAF1) [RAF1]
B, M, B1, A1, A2, B2

Handling information


UA Rapp
Cross references
GenBank X03484
GenBank 168216

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Intended use
This product is intended for laboratory research use only. It is not intended for any animal or human therapeutic use, any human or animal consumption, or any diagnostic use.

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Curated Citations

Hall JM, et al. Oncogenes and human breast cancer. Am. J. Hum. Genet. 44: 577-584, 1989. PubMed: 2564734

Bonner TI, et al. Structure and biological activity of human homologs of the raf/mil oncogene. Mol. Cell. Biol. 5: 1400-1407, 1985. PubMed: 2993863

Elliott RW, et al. Localization of the rhodopsin gene to the distal half of mouse chromosome 6. Genomics 6: 635-644, 1990. PubMed: 2341153

Vance JM, et al. Confirmation of linkage in von Hippel-Lindau disease. Genomics 6: 565-567, 1990. PubMed: 2328994

Bonner TI, et al. The complete coding sequence of the human raf oncogene and the corresponding structure of the c-raf-1 gene. Nucleic Acids Res. 14: 1009-1015, 1986. PubMed: 3003687

View All Curated Citations for this Product

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