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pv-sis [SISR12]


simian sarcoma virus (type C)
Clone type
Molecular biology
Product format
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Detailed product information


Restriction digests of the clone give the following sizes (kb): EcoRI--6.0; PstI--4.8, 1.2.
A 1.0 kb PstI/XbaI fragment contains v-sis but no helper virus sequences.
Contains nt 4052-5122 of the published sequence, including most of coding sequence for v-sis, a polyadenylation signal, the v-sis helper virus junction, the coding sequence for p15E, and part of an LTR.
Mycoplasma contamination
Not detected

Vector information

Construct size (kb)

Insert information

Insert size (kb)
Type of DNA
Gene product
platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)(platelet-derived growth factor, beta polypeptide) [SIS]
B1, B2, B1, B2


HM Temin, SA Aaronson
Cross references
GenBank J02396
GenBank 165086

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Intended use
This product is intended for laboratory research use only. It is not intended for any animal or human therapeutic use, any human or animal consumption, or any diagnostic use.

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While ATCC uses reasonable efforts to include accurate and up-to-date information on this product sheet, ATCC makes no warranties or representations as to its accuracy. Citations from scientific literature and patents are provided for informational purposes only. ATCC does not warrant that such information has been confirmed to be accurate or complete and the customer bears the sole responsibility of confirming the accuracy and completeness of any such information.

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Permits & Restrictions

Import Permit for the State of Hawaii

If shipping to the U.S. state of Hawaii, you must provide either an import permit or documentation stating that an import permit is not required. We cannot ship this item until we receive this documentation. Contact the Hawaii Department of Agriculture (HDOA), Plant Industry Division, Plant Quarantine Branch to determine if an import permit is required.



Curated Citations

Fabisiak JP, et al. Increased expression of PDGF-B (c-sis) mRNA in rat lung precedes DNA synthesis and tissue repair during chronic hypoxia. Am. J. Respir. Cell Mol. Biol. 1: 181-189, 1989. PubMed: 2696512

Radice P, et al. Loss of heterozygosity in human germinal tumors. Cytogenet. Cell Genet. 52: 72-76, 1989. PubMed: 2612217

Kochevar DT, et al. Low level amplification of c-sis and c-myc in a spontaneous osteosarcoma model. Cancer Lett. 53: 213-222, 1990. PubMed: 2208081

Robbins KC, et al. Molecular cloning of integrated simian sarcoma virus: genome organization of infectious DNA clones. Proc. Natl. Acad. Sci. USA 78: 2918-2922, 1981. PubMed: 6265924

Devare SG, et al. Nucleotide sequence of the simian sarcoma virus genome: demonstration that its acquired cellular sequences encode the transforming gene product p28sis. Proc. Natl. Acad. Sci. USA 80: 731-735, 1983. PubMed: 6298772

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