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Human Cancer Models Initiative (HCMI)

When standard models fall short, transition to patient‑derived systems designed for predictive, translatable results


When to use HCMI models

When standard models stop predicting outcomes, it is time to reassess your model system. Use HCMI models when tumor biology must reflect patient reality, when translational risk cannot be tolerated, and when experimental conclusions need to hold as research moves from discovery to validation.

Explore HCMI models

Browse patient-derived HCMI models from ATCC, including organoids and non-organoid systems, each authenticated and accompanied by clinical and genomic annotations.

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Organoids

HCMI organoids from ATCC deliver patient-derived, clinically annotated cancer models that preserve tumor biology and heterogeneity.

Browse organoids

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2-D, neurosphere, and other models

HCMI neurospheres, conditionally reprogrammed cells, and 2-D cell models from ATCC deliver patient-derived, clinically annotated cancer systems that support diverse experimental needs.

Browse the models

Grounded in patient biology and clinical data

Each model is developed from primary tumor specimens and paired with de-identified clinical annotations and comprehensive genomic data, giving researchers the biological and clinical context needed for translational and precision medicine research. As HCMI's sole distributor, ATCC manufactures, quality controls, and distributes these materials at scale with the consistency and rigor the work demands.

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How to use the HCMI Searchable Catalog

Before ordering, explore available genomic and clinical data for HCMI models through the searchable catalog. Filter by diagnosis, gene alterations, clinical stage, patient demographics, and model characteristics to select models that align with your research and improve predictive relevance. Once you’ve identified the right models, return to ATCC to complete your order.

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