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Application notes

Advanced biological models and credible reference standards enable greater specificity and functionality to the researcher’s toolkit. Browse our growing collection of application notes for access to in-depth data on the development and validation of these products and to explore proof-of-concept studies focused on their various applications.

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A digitally colorized transmission electron micrograph shows Avian Influenza A (H5N1) virus particles highlighted in gold within infected Madin‑Darby Canine Kidney (MDCK) epithelial cells shown in green. Numerous elongated and spherical virions are visible among cellular membranes, illustrating viral replication inside host cells. Application note

Performance Assessment of Avian Influenza Virus Analytical Reference Materials for Diagnostic Surveillance: Subtypes H5N1, H7N9, H7N7, H5N6, and H9N2

This application note demonstrates the development and validation of quantitative synthetic RNA reference materials for Avian influenza subtypes H5N1, H7N9, H7N7, H5N6, and H9N2.

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Monkeypox virus Application note

Performance Assessment of ATCC® Quantitative Synthetic Analytical Reference Material for Human Monkeypox Virus (hMPXV)

In this application note, we evaluate the performance of the synthetic hMPXV analytical reference material and demonstrate its reliability as a safe, BSL‑1 positive control compatible with multiple published qPCR assays targeting both Clade I and Clade II monkeypox virus.

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Spheroid pre-plated kit plate to measure OD with microplate reader. Microtiter plate (96 well) reader for biochemistry analysis. Application note

ThawReady™: New Effortless 3-D Technology Overcoming the Challenge of Traditional Spheroids

In this application note, discover how ThawReady™ 3‑D Spheroid Kits provide an effortless, integrated solution that overcomes the media‑exchange, handling, and reproducibility challenges of traditional spheroid culture systems.

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 Transparent bubble of Chlamydia bacteria. Application note

Performance Assessment of Quantitative Synthetic Chlamydia trachomatis LGV I, II, and III Reference Materials for qPCR Applications

This application note demonstrates the development and validation of quantitative synthetic DNA reference materials for Chlamydia trachomatis LGV serovars I–III.

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Fluorescent microscopy showing fibroblast cells with bright red nuclei and an intricate network of blue-stained cytoskeletal fibers. Application note

Immortalized Human Dermal Fibroblasts: Consistent, Reproducible, and Physiologically Relevant Models for Skin Biology Studies

This application note presents an immortalized human dermal fibroblast cell line validated for reproducible toxicity testing and 3‑D skin modeling.

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Detailed 3D rendering of a tooth cross-section highlighting internal structures such as nerves and blood vessels, surrounded by healthy teeth on a white background. Perfect for dental education, oral health resources, and anatomy visuals. Application note

Multipotency in Dental Stem Cells

In this application note, we confirm the multipotency of the novel SCAP line DSCS.

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