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Elevating biological models of metastasis

In this webinar, ATCC epithelial-to-mesenchymal transition expert and Senior Biologist Diana Douglas will cover the following key points:

  • CRISPR/Cas9 genome-editing technology was applied to develop a number of RFP- or GFP-tagged reporter cell lines to study EMT and MET phenomena.
  • The EMT/MET reporter cell lines can be used to monitor cellular changes in real time or as a platform for drug screening.
  • In depth transition data were generated including morphology change, intrinsic reporter expression, marker expression, and invasion upon stimulation with EMT/MET agonists.

Use of exosomes as reference materials in biomedical research

Dr. Siddhartha Paul is an expert in the isolation and characterization of extracellular vesicles. In this presentation, Dr. Paul gives an overview of exosomes from various well-characterized ATCC cell lines and shows data indicating that these extracellular vesicles can be used as reference materials in biological research and assay development.

  • There is an unmet need for well-characterized exosome reference materials.
  • Exosomes from ATCC cells can serve as consistent, natural standards for molecular assay development or utilized to develop novel drug delivery systems.
  • ATCC experts generated characterization and application data indicating that exosomes can be implemented in multiple functional assays.