Since the identification of the first human case of mpox (formerly monkeypox) in 1970,1 the monkeypox virus has become endemic to several countries in central and western Africa and has rarely been detected in humans in other regions of the world. But that may be changing. Recently, hundreds of cases have been confirmed in other continents. The Centers for Disease Control and Prevention (CDC) is actively tracking cases and as of June 14, 2022 reported over 1800 confirmed mpox and Orthopoxvirus cases across 35 countries.