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Human Cancer Models Initiative (HCMI)

When standard models fall short, transition to patient‑derived systems designed for predictive, translatable results


Grounded in patient biology and clinical data

HCMI, a decade-long international collaboration, represents one of the world's most extensive and diverse collections of next-generation cancer models, each paired with rich clinical and genomic datasets, including key patient and disease characteristics. Available exclusively through ATCC, these models undergo standardized characterization, extensive data annotation, rigorous authentication, and quality-controlled biobanking, providing researchers with well-defined, ready-to-use, and highly characterized resources for translational cancer research.

Defining the Next Generation of Nonclinical Research

ATCC advanced models are helping enable new approach methodologies (NAMs) that bring greater human relevance to nonclinical research. See how ATCC is advancing organoid and microphysiological system (MPS) platforms for applications across oncology, infectious disease, and beyond.

Read the press release

Explore HCMI models

Browse patient-derived HCMI models from ATCC, including organoids and non-organoid systems, each authenticated and accompanied by clinical and genomic annotations.

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Organoids

HCMI organoids from ATCC deliver patient-derived, clinically annotated cancer models that preserve tumor biology and heterogeneity.

Browse organoids

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2-D, neurosphere, and other models

HCMI neurospheres, conditionally reprogrammed cells, and 2-D cell models from ATCC deliver patient-derived, clinically annotated cancer systems that support diverse experimental needs.

Browse other models

How to use the HCMI Searchable Catalog

Before ordering, explore available genomic and clinical data for HCMI models through the searchable catalog. Filter by diagnosis, gene alterations, clinical stage, patient demographics, and model characteristics to select models that align with your research and improve predictive relevance. Once you’ve identified the right models, return to ATCC to complete your order.

Explore the HCMI Searchable Catalog , opens in a new tab

Resources