Toxicological Models Matter: Human Cell Strategies for ADME, DMPK, and Safety Workflows
March 12, 2026, at 12:00 PM ETSelecting the right in vitro model is critical for generating predictive, human-relevant ADME, DMPK, and safety data in your toxicology research. This webinar explores how primary and hTERT-immortalized primary cells can be used individually or in combination within toxicology workflows. We will provide practical guidance on aligning model selection with your study goals to improve study outcomes and reduce late-stage failures. Additionally, we will showcase data from experiments using primary human hepatocytes, peripheral blood mononuclear cells (PBMCs), and hTERT-immortalized primary renal proximal tubule epithelial cells (RPTEC). Be sure to stay for the lively Q & A session at the end of the presentation.
Key takeaways:
- How to choose appropriate human cell models for ADME, DMPK, and toxicity studies
- Strengths of primary hepatocyte, PBMC, and hTERT-immortalized renal tubule cells in toxicology workflows and applications
- Using human-relevant systems can improve decision-making and reduce late stage setbacks
Presenter:
Ashley Cox, PhD
Field Application Specialist, ATCC
Ashley Cox is a Field Application Specialist at ATCC where she provides support and technical expertise in toxicology and cell biology. She obtained her Ph.D. from the Marshall University Joan C. Edwards School of Medicine in biomedical research, with a focus on toxicology. Prior to joining ATCC, Dr. Cox’s research focused on identifying toxicological and cellular stress effects of flavoring aldehydes in vaping products using an in vitro renal model. In addition, her previous experiences as an instructor have helped shape her expertise in science education and communication. Today, she supports ATCC customers in the toxicology research space to help overcome experimental challenges and build robust in vitro workflows.
