iPSC-derived Primary Cells: Expand Your Cell-based Assays With an Unlimited, Biologically Relevant SourceJun 27, 2019 at 12:00 PM ET
Toxicology and cancer researchers alike are challenged by the lack of a consistent source of cells with high physiological relevance for their cell-based assays. The source tissue for primary cells comes from a variety of donors, which can introduce interexperimental variability and confound experimental results. Differentiated induced pluripotent stem cell (iPSC)-derived cells fulfill the need for a consistent source of cells and physiological relevance. iPSCs are able to be generated in large cell numbers from a single clone, providing the needed consistency. Further, iPSCs can be differentiated into a variety of desired, functional cell types, affording the necessary biological relevance. Here we provide data demonstrating how differentiated iPSC-derived cells can be incorporated into immunoassays or further differentiated into cell types such as osteocytes, chondrocytes, and adipocytes.
- Differentiated iPSCs lend the ability to run large toxicity studies and drug screens on highly biologically relevant cells.
- ATCC iPSCs were used as the source for three types of differentiated cells: CD34+ progenitors, mesenchymal stem cells (MSCs), and monocytes.
- ATCC R&D scientists have generated in-depth data showing the iPSC-derived cells can be incorporated into immunoassays and further differentiated into cell types such as osteocytes, chondrocytes, and adipocytes.
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Yalin Firinci, MBA
Product Line Business Specialist, ATCC
Yalin Firinci, M.B.A., works in product line business management with a focus on stem cells, immortalized primary cells, induced pluripotent stem cell-derived cells, and classical cell culture product lines. Previously he worked as a life science consultant at Avalere Health, a project manager at BioReliance, and interned as an API supply chain specialist at Pfizer. Yalin received a B.S. in Biology and an M.B.A. focusing on Finance from The George Washington University.