Abstract
This presentation introduces a novel microphysiological model designed to mimic the gut-hepatic barrier that utilizes ATCC HepatoXcell Primary Human Hepatocytes and Caco-2 cells. The model employs the Locsense Artemis instrument to measure transepithelial electrical resistance (TEER), providing insights into barrier integrity. This study highlights the model's potential for advancing our understanding of gut-liver interactions, offering a robust platform for drug testing and toxicity studies.
Download the presentation to learn about a microphysiological model designed to mimic the gut-hepatic barrier
DownloadPresenters
Sujoy Lahiri, PhD
Lead Scientist, R&D, ATCC
Sujoy Lahiri, PhD, is an R&D scientist in ATCC. He leads the primary cell division, working on advanced cellular models using primary cells as well as expansion of ATCC’s primary cell portfolio. Dr. Lahiri has extensive knowledge in the field of toxicology and drug metabolism.
Susan Roelofs, PhD
CEO and Founder, Locsense
Dr. Susan Roelofs is the CEO and founder of Locsense B.V., a pioneering laboratory equipment company situated in Enschede, Netherlands. There, she is responsible for strategy and operations. Dr. Roelofs obtained her MSc. degree in Applied Physics from the University of Twente with a specialization in Biophysical Engineering. She completed her PhD in Lab-on-Chip technology at the University of Twente in 2015.
Locsense focuses on the development of in-vitro sensing equipment. Currently Locsense’ team consists of 10 persons. Since 2019, Locsense has successfully launched new products, including their flagship device, the Artemis Impedance spectrometer / TEER detector.
Primary human hepatocytes are considered the gold standard for in vitro liver models due to their high predictive value in drug metabolism and toxicity studies. They can provide early insights into how a drug will behave in the human body, potentially reducing the risk of adverse effects in clinical trials. ATCC hepatocytes are meticulously isolated and characterized to ensure the highest quality and performance for your drug development and toxicity testing needs. Try our HepatoXcell™ primary human hepatocytes and media today!
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