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Models Providing High Biological Relevance and Predictability in Toxicological Assays

Green and blue NuLi lung epithelial small airway cells.

Abstract

Developing cell-based assays can be problematic; the cells must be physiologically relevant for the assay to be predictive, yet sufficiently abundant to be included in the assay without introducing interexperimental variability. hTERT-immortalized primary cells address both issues. Primary cells exhibit the highest biological relevance and hTERT-immortalized primary cells exhibit the growth characteristics of continuous cell lines with physiological attributes of primary cells. In this presentation, ATCC experts discussed the characteristics and utility of various respiratory, skin, and kidney models in toxicological assays.

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