Sexually Transmitted Diseases

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Sexually transmitted infections (STIs) have a major impact to the sexual and reproductive health of humans around the globe. In fact, the World Health Organization estimates that there are over one million new infections acquired every day.

While some STIs—such as hepatitis B, herpes, human papillomavirus, or HIV—cause incurable, lifelong disease, others such as gonorrhea, trichomoniasis, syphilis, or chlamydia can be cured with antimicrobial treatment. The availability of effective treatment options combined with the early detection and subsequent repeat testing during treatment therefore become vital for improving patient outcomes and managing disease.

To support researchers in the development and validation of vaccines, novel drugs, and detection methods, ATCC provides a wide range of authenticated microorganisms, molecular standards, and cell lines. Our microbial strains are backed by meticulous laboratory procedures and represent ATCC's high standards of quality for microorganisms, including full characterization of each strain to establish identity, utilization of a seed stock system to minimize subculturing, and careful preservation for culture maintenance. Likewise, our molecular standards are fully authenticated and characterized to confirm integrity, purity, concentration, functionality, and identity. These reference materials are provided as high-quality DNA and RNA preparations that were isolated or synthetically derived under aseptic conditions to prevent cross-contamination.

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Molecular standards for STIs

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External validation of ATCC molecular standards for Herpes simplex virus (HSV-1 and HSV-2)

HSV-1 and HSV-2 cause a wide range of clinical manifestations that result in lifelong infections. Quantitative PCR (qPCR) assays are routinely used for the detection of herpes infections in clinical samples. However, the accuracy of these assays is dependent upon the generation of a standard curve using a positive control with a known genome copy number. To support this need, ATCC has developed HSV-1 and HSV-2 quantitative molecular standards for use as controls for the detection and quantification of these viruses from clinical samples.

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Development of synthetic molecular standards for Hepatitis B (HBV) and Hepatitis C virus (HCV)

Viral hepatitis caused by HBV and HCV is a major health concern that affects millions of people worldwide. Since these viruses are difficult to culture in vitro, obtaining control material for molecular-based assays is a challenge. To address this problem, ATCC has developed quantitative synthetic molecular standards for HBV and HCV that can be used as controls in molecular assays designed to detect and quantify these viruses from clinical samples.

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