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Blood-borne Diseases

Green human umbilical vein endothelial cells.

Discover reference materials for sepsis and blood-borne disease research

The accuracy and precision of assays designed to screen donor blood, tissues, and artificial implants for communicable diseases and contaminants are essential for preventing sepsis and the spread of blood-borne pathogens. ATCC is committed to supporting the development and validation of these assays by providing a wide range of authenticated biological and molecular reference materials. Our growing portfolio includes microorganisms isolated from blood, persistently infected cells, genomic and synthetic nucleic acids, and host cell lines.

These products provide essential tools for assay development, inclusivity and exclusivity testing, and evaluating the limit of detection. They are supported by genotypic, phenotypic, and functional analyses to ensure authenticity, so you can trust your results and reproduce your data.

Blood-borne disease research

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Development of synthetic molecular standards for hepatitis research

The detection and monitoring of viral hepatitis typically relies on the use of molecular-based methods. Because Hepatitis B (HBV) and Hepatitis C virus (HCV) are difficult to culture in vitro, obtaining control material for these assays is a challenge. To address this issue, ATCC has developed quantitative synthetic molecular standards for HBV and HCV, as well as HAV and HEV. These preparations are stable, can be handled in biosafety level one facilities, and are compatible with numerous published protocols. Read our application note to explore the development and validation of these materials.

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Challenges and solutions in the development of molecular-based assays

Molecular-based assays are powerful and precise diagnostic tools for the detection of clinically relevant infectious agents. However, while these assays demonstrate several advantages over traditional culture-based approaches, great care must be taken to ensure that assays are properly validated to guarantee performance and uncompromised data. Read our white paper to learn more about the challenges associated with the development and validation of molecular-based assays and discover guidance on selecting the ideal reference materials.

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