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Extracellular Vesicles: For Better and For Worse

Extracellular Vesicles: For Better and For Worse

Extracellular vesicles (EVs), such as exosomes, are nano-sized particles secreted by all cell types. Because of their ability to transfer a wide variety of biological cargo from donor to recipient cells, EVs have the potential to exert potent effects. Depending on the source of the donor cells, these effects may be either beneficial or harmful to recipient cells. For example, recent advancements in EV purification methods have allowed for the efficient separation of EVs away from virus in virally infected cells. Characterization of these damaging EVs has revealed the presence of viral material, and functional analyses have suggested that these EVs elicit adverse effects in uninfected recipient cells. On the other hand, EVs from human stem cells have demonstrated the ability to contribute to wound healing, angiogenesis, and immunomodulation. Therefore, these reparative EVs hold great promise for the future of regenerative medicine. This webinar will highlight recent research surrounding both damaging EVs from infected cells and reparative EVs from stem cells and discuss their potential applications for diagnostic and therapeutic purposes.