Discovering ATCC Primary Immune Cells: Model Systems to Study the Immune and Cardiovascular Systems

Hematopoietic stem cells (HSCs) are capable of differentiating into the formed elements of blood: leukocytes, erythrocytes, and thrombocytes. While these distinct cell types display specific immune, transport, and hemostatic phenotypic functions, they are all derived from HSCs. In this webinar we will present data showing that ATCC marrow- and blood-derived primary immune cells, such as bone marrow and cord blood CD34+ cells as well as peripheral blood CD14+ monocytes can be induced to differentiate into various hematopoietic lineages. This webinar will also highlight the use of peripheral blood mononuclear cells to investigate the immunosuppressive capabilities of primary and hTERT-immortalized mesenchymal stem cells in a T-cell proliferation assay.

Key Points

• HSCs are a rapidly advancing area of research producing insights into cellular plasticity, immune function, and disease.
• Cryopreserved, purified blood cells can be cultured in vitro and induced to differentiate into downstream lineages or used for functional assays.
• ATCC offers a variety of blood cell type from multiple tissues that are useful in many applications and research areas.