Two of the major challenges that many scientists experience when developing a cell-based assay include obtaining cells with high biological relevance and then producing or procuring enough cells to run the assay without introducing cell variability. hTERT-immortalized primary cells address both issues. These cells are genetically modified such that the cells exhibit the growth characteristics of a continuous cell line but maintain the physiology of a primary cell. In this webinar, ATCC scientists will discuss our broad portfolio of hTERT-immortalized primary cells and provide some application data to illustrate how these cell models can easily be incorporated into your workflow. Special emphasis will be placed upon our new kidney transporter models for predictive toxicology (RPTEC/TERT1 OAT1, RPTEC/TERT1 OCT2, and RPTEC/TERT1 OAT3).

Key Points:

  • There is a lack of in vitro models that durably and correctly recapitulate in vivo physiology
  • hTERT-immortalized primary cells solve the problem of limited biological relevancy in cell-based assays
  • hTERT-immortalized primary cells exhibit the growth characteristics of a continuous cell line but maintain the physiology of a primary cell
  • ATCC has created kidney cell models using a well-characterized hTERT-immortalized RPTEC that stably overexpress the OAT1, OCT2, or OAT3 gene; our data show that these modified cell lines are very useful tools that provide kidney tissue-relevant results, improved consistency over time, and predictability for clinical trials

6/7/2018 — 6/11/2018

Atlanta GA

Booth: 1510 & 1514

ASM Microbe 2018 (June 7-11, 2017, Atlanta, GA) showcases the best microbial sciences in the world, and provides a one-of-a-kind forum to explore the complete spectrum of microbiology from basic science to translation and application.

6/11/2018 — 6/14/2018

Manassas, VA

The ATCC-GMU School of System Biology annual workshop is designed to provide an overview of Best Practices in Cell Culture through classroom presentation and laboratory work. This Workshop is intended for trainees with no prior experience in basic cell culture techniques.

Topics include the following Best Practices for:

  • Designing and using laboratory space for cell culture
  • Receiving and managing cells in culture
  • Naming cell lines
  • Selecting media for culturing mammalian cell
  • Authenticating cell lines
  • Detecting and mitigating the risk of cell culture contaminants
  • Cryopreserving, thawing and recovering and assessing cells
  • Storing and shipping cryopreserved cells
ATCC scientist examining a container of media

This 4-day workshop employs an integrated approach – utilizing hands-on training to reinforce lecture material – enabling trainees to translate culture techniques into applications in their own laboratories.

7/14/2018 — 7/18/2018

College Park MD

ASTMH 67th Annual Meeting 2018

Precision Medicine Starts Here

10/28/2018 — 11/1/2018

New Orleans LA

The ASTMH Annual Meeting is a five-day educational conference that draws nearly 4,500 attendees -researchers, physicians in global health and tropical and travel disease, military personnel and public health officials from around the world.

AMP 2018

AMP 2018

11/1/2018 — 11/3/2018

San Antonio, TX

Booth: 701

AMP 2018 brings together key researchers in every aspect of molecular diagnostics, including Interpretation & Reporting of Molecular Diagnostic Tests, Assay Development, Validation & Performance, & Translational Research.