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ASTMH 67th Annual Meeting 2018

Precision Medicine Starts Here

10/28/2018 — 11/1/2018

New Orleans LA

The ASTMH Annual Meeting is a five-day educational conference that draws nearly 4,500 attendees -researchers, physicians in global health and tropical and travel disease, military personnel and public health officials from around the world.

11/1/2018 — 11/3/2018

San Antonio, TX

Booth: 701

AMP 2018 brings together key researchers in every aspect of molecular diagnostics, including Interpretation & Reporting of Molecular Diagnostic Tests, Assay Development, Validation & Performance, & Translational Research.

11/3/2018 — 11/7/2018

San Diego, CA

Booth: 3326

Society for Neuroscience's 48th annual meeting, Neuroscience 2018, is the world's largest neuroscience conference for scientists and physicians devoted to understanding the brain and nervous system.


Poster Sessions

Comprehensive gene expression analysis and neurotoxicity testing of human iPSC-derived neural progenitor cells and neurons
Tuesday Nov 6, 2018 8:00 AM - 12:00 PM, Abstract # 11048, Session # 473

CRISPR/Cas9-engineered IDH1R132H isogenic luciferase expressing cell models for in vitro and in vivo glioma studies
Tuesday Nov 6, 2018 8:00 AM - 12:00 PM, Abstract # 15097, Session # 518


EMT Reporter Cell Lines

New Tools for Metastasis Studies

11/15/2018

Epithelial-mesenchymal transition (EMT) describes a cellular process during which differentiated epithelial cells lose their epithelial features and gain mesenchymal properties. EMT has been implicated in the invasion-metastasis cascade hallmark of cancer; cells undergoing EMT display an ability to promote metastasis and elevated drug resistance. Therefore, an in vitro EMT reporter cell model is a valuable tool for dissecting EMT molecular pathways and screening therapeutic compounds. ATCC recently created novel EMT reporter knock-in cell lines by using CRISPR/Cas9 genome-editing technology. These EMT reporter cells faithfully recapitulate the endogenous EMT marker expression; in response to treatment, the reporter cells undergo EMT, enabling real-time monitoring of dynamic EMT intermediate states in live cells. Further, we present application data indicating that pathway- specific inhibitors can block EMT in a dose-dependent matter.